Biochemical Effects of Olea europaea L. and Zingiber officinale on Ehrlich Ascites Carcinoma in Mice | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 62, Issue 4, August 2023, Page 13-21 PDF (1.68 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcc.2023.411558 | ||||
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| Authors | ||||
| Amany Yehia* 1; Manar Refaat1; Magdy M. Youssef2 | ||||
| 1Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt | ||||
| 2Chemistry Department, Faculty of Science, Mansoura University | ||||
| Abstract | ||||
| Cancer is an important health problem worldwide, killing 10 million people each year. Antioxidant and anticancer medicinal plants are widely used in traditional medicine to treat a wide range of diseases. The objective of this study was to evaluate the efficacy of olive leaf extract and ginger extract in treating mice with Ehrlich ascites carcinoma (EAC). 48 mice were split into eight groups (n = 6) after tumor induction, and for 14 days, daily doses of 150 mg/kg of the extracts were administered to each group. Mice were sacrificed after the experiment, serum and tissues were obtained, and biochemical and molecular parameters were measured. Oral administration of OLE and ginger extracts leads to a substantial reduction in tumor volume, MDA activities, and liver enzyme activity, as well as an increase in SOD and GPx levels in the treated groups. The present research shows that olive leaf and ginger extracts have antitumor activity in vivo, which results in biochemical parameter normalization when compared to EAC bearing mice. | ||||
| Keywords | ||||
| Ehrlich ascites carcinoma; Antioxidants; Antitumor; Flavonoids | ||||
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