Resection of The Primary Tumor in Patients with Metastatic Breast Cancer, Impact on Patients’ Survival, A Comparative Retrospective Study | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 112, Volume 98, Issue 1, January 2025, Page 772-788 PDF (987.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.411583 | ||||
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| Abstract | ||||
| Background: Traditionally the treatment for women with metastatic breast cancer (MBC) is systemic therapy; surgery is for palliation or complications. Recently, challenges suggesting that primary tumor resection improve survival. Aim of the work: This study was to evaluate surgical resection of primary breast tumor in female patients with MBC. Patients and methods: The study included 230 females with MBC presented at Tanta University Hospital and Damanhour Medical National Institute throughout four years periods. They divided into two groups; Group (A); included 120 patients subjected to surgical resection to primary breast tumor and Group (B); included 110 patients subjected to non-surgical therapy for their primary breast tumor. We compared overall survival (OS), progression free survival (PFS) and other prognostic factors between both groups. Results:The OS of surgical group was significantly longer than control group and PFS of those patients were better than controls but without significance. This outcome was more evident in patients with bone only metastases and/or with solitary or oligo-metastatic site(s). Conclusion: In MBC radical surgery should have free margins. Wide local excision and mastectomy had equivocal results. Patients presented with bone only and/or solitary or oligo-metastatic site(s) have good outcome than controls and those with visceral and/or multiple metastatic sites. | ||||
| Keywords | ||||
| MBC, Metastatic breast cancer; OS, Overall Survival; PFS, Progressive Free Survival | ||||
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