Role of Insulin Like growth factor in non-alcoholic fatty liver Egyptian patients

Hanna, Demiana H.; Ameen, Asmaa; Elagawy, Waleed; Elmahdy, Reem; Hegab, Wafaa Salah Mohamed; Shaheen, Mahmoud M; Ibrahim, Randa; Fawzy, Naglaa; Mohamed, Amal; El Desouky, Mohamed A. A.

doi:10.21608/ajbs.2025.347038.1116

	Role of Insulin Like growth factor in non-alcoholic fatty liver Egyptian patients
African Journal of Biological Sciences
Articles in Press, Accepted Manuscript, Available Online from 14 February 2025
Document Type: Original Article
DOI: 10.21608/ajbs.2025.347038.1116
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Authors
Demiana H. Hanna ¹; Asmaa Ameen²; Waleed Elagawy³; Reem Elmahdy⁴; Wafaa Salah Mohamed Hegab⁵; Mahmoud M Shaheen⁶; Randa Ibrahim⁷; Naglaa Fawzy⁸; Amal Mohamed⁹; Mohamed A. A. El Desouky²
¹Cairo, Giza
²Cairo University, Faculty of Science
³2Department of Tropical Medicine, Faculty of Medicine, Port Said University, Port Fouad.
⁴3Internal Medicine department, faculty of Medicine, Suez Canal University, Suez, Egypt
⁵Internal medicine department, National diabetes institute, The general organization for teaching hospitals and institute Cairo, Egypt
⁶, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
⁷Clinical and Chemical Pathology Department, Nutrition institute GOTHI ; Cairo, Egypt
⁸Clinical and Chemical Pathology Department, National Institute of Diabetes and Endocrinology, Cairo, Egypt.
⁹Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, GOTHI, Cairo, Egypt
Abstract
Background: Investigate the level of serum insulin growth factor in non-alcoholic fatty liver disease compared with healthy subjects. Methods: The current study included two hundred and seven participants, which divided into 100 were diagnosed as non-alcoholic fatty liver disease and 107 healthy participants, which were collected from National Hepatology and Tropical Medicine Research Institute, Egypt. All participants subjected to measure the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, creatinine, fasting blood glucose, Homa-IR, Triglycerides (T.G), Total cholesterol, High-density lipoprotein (HDL), and Low-density lipoprotein (LDL) were measured using Beckman 480 by auto analyzer biochemistry. In addition to insulin like growth factor-1(IGF), Interleukin-6 (IL-6) and fasting Insulin level were done by Elisa technique according to manufacturer instruction. Results: The current study showed that there was significant increase in the body mass index, fasting blood glucose, Homa IR, ALT, AST, GGT, HDL , LDL, albumin and total bilirubin in NAFLD group compared to control group (P ≤ 0.000), while there was significant decrease in the fasting insulin level, total cholesterol, triglycerides ,and creatinine in NAFLD group compared to control group (P > 0.05). As a regard of interleukin-6 and insulin growth factor there was significant increase in the mean values in NAFLD group compared to control group. Conclusion: The obtained findings suggested that there was negative correlation between insulin like growth hormone levels, body mass index and interleukin-6. Serum levels of insulin like growth factor were low in non-alcoholic fatty liver compared to control group.
Keywords
NAFLD; IGF-1; BMI; IL-6; obesity


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