Uterine Artery Doppler and Serum Pentraxin-3 Level in Preeclampsia and Its Correlation to Intrauterine Growth Restriction | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 118, Volume 98, Issue 1, January 2025, Page 828-832 PDF (311.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.411715 | ||||
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| Abstract | ||||
| Background: Preeclampsia (PE) is a pregnancy-specific condition associated with hypertension and proteinuria, often leading to intrauterine growth restriction (IUGR). Pentraxin 3 (PTX-3), an inflammatory molecule, has been linked to the pathophysiology of PE, with increased levels in women with established PE. Objective: This study aimed to evaluate the utility of PTX-3 as a biomarker in pregnancies with abnormal uterine artery Doppler and its correlation with IUGR. Patients and Methods: A retrospective cohort study was conducted at Banha University Hospital on 80 women in their third trimester. Participants were categorized into four groups: control (normotensive), mild PE, severe PE, and severe PE with IUGR. Serum PTX-3 levels, uterine artery Doppler indices, blood pressure, and proteinuria were assessed. Results: Serum PTX-3 levels significantly increased across the groups, with levels of 2.83±1.38 ng/ml in controls, 9.34±1.48 ng/ml in mild PE, 25.19±2.87 ng/ml in severe PE, and 31.78±1.66 ng/ml in severe PE with IUGR (p < 0.0001). Doppler indices, including systolic (p < 0.0001) and diastolic blood pressure (p < 0.0001), also showed significant differences. PTX-3 correlated positively with systolic blood pressure (r=0.84, p < 0.0001), diastolic blood pressure (r=0.71, p < 0.0001), proteinuria (r=0.68, p < 0.0001), and Doppler indices (r=0.86, p < 0.0001). Conclusion: PTX-3 levels are significantly elevated in women with PE and IUGR, correlating strongly with clinical parameters such as blood pressure, proteinuria, and Doppler indices. PTX-3 may serve as a valuable biomarker for assessing the severity of PE and predicting IUGR. | ||||
| Keywords | ||||
| Preeclampsia; Pentraxin 3; Intrauterine Growth Restriction; Doppler Indices | ||||
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