Effects of resistance exercise on fibromyalgia: a signaling pathway on mitochondrial functions.

Abd-allatif, Seham Abd-Alrahman; Monir, Dina; Mahmoud, Motamed; Mahmoud, Aida Abdeen; Mahrous, Sohair Maher; Ahmed, Hoda Mostafa

doi:10.21608/smj.2025.350539.1524

	Effects of resistance exercise on fibromyalgia: a signaling pathway on mitochondrial functions.
Sohag Medical Journal
Volume 29, Issue 1., 2025, Page 87-94 PDF (790.88 K)
Document Type: Review Article
DOI: 10.21608/smj.2025.350539.1524
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Authors
Seham Abd-Alrahman Abd-allatif ¹; Dina Monir²; Motamed Mahmoud³; Aida Abdeen Mahmoud⁴; Sohair Maher Mahrous⁵; Hoda Mostafa Ahmed⁶
¹physiology department.faculty of medicine,sohag university.
²Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt
³Department of Animal Behavior and Husbandry, Faculty of Veterinary Medicine, Sohag, University, Sohag, Egypt
⁴Department of Biochemistry, Faculty of Medicine, Sohag University
⁵Rheumatology department faculty of medicine sohag university hospitals
⁶Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Abstract
Fibromyalgia (FM) is one of the most prevalent disorders that affects the muscular tissue and is characterized by pain, stiffness, and soreness in the muscles, tendons, and joints. FM affects about 5% of the world population. The incidence is higher in women than in men. However, the pathophysiological factors of FM are not yet well known. Mitochondrial dysfunction may have a role in the pathogenesis of FM but the exact mechanism is unclear. Mitochondrial dysfunction was associated with increased expression of autophagic genes and the elimination of dysfunctional mitochondria by mitophagy . Exercise increases mitochondrial capacity, oxidative phosphorylation, and mitochondrial respiratory capacity. Resistance exercise may improve the mitochondrial quality probably through increasing mitophagy through PINK1/PARKIN pathway. Therefore, resistant exercise could be an important part of managing FM. The purpose of this review is to update information on the effects of resistance exercise on FM, specifically in relation to signaling pathways and biological processes.
Keywords
Mitochondrion; Mitophagy; PINK; PARKIN
Supplementary Files smj.2025.350539.pdf

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