A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture
Mostafa, A., Elsayed, B., Meslhy, E., Omar, N., Khalaf, M., Aboelkhair, M., Elsayed, S., Hesham, R., Hosni, A., Ibrahim, A., Mohsen, B., Mohamed, N., Mohamed, A., Ahmed, M., Mostsfa, N., Ashraf, E., Bataa, A., Elsayed, E., Youssef, M., Amer, A., Sabry, A., Ahmed, S. (2025). A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture. EKB Journal Management System, (), -. doi: 10.21608/erurj.2025.314637.1178
Alaa Ahmed Mostafa; Bassant Elsayed; Esraa Meslhy; Nermeen Omar; Mohamed Khalaf; Mai Aboelkhair; Sara Elsayed; Rawan Hesham; Abdallah Ahmed Hosni; Ahmed Mounir Ibrahim; Basel Mohsen; Nourhan Mohamed; Ahmed Mohamed; Mahmoud Ahmed; Nada Mostsfa; Ebtehal Ashraf; Aya Bataa; Esraa Elsayed; Mohamed Youssef; Ahmed Sheref Amer; Amira Sabry; Saad Ahmed. "A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture". EKB Journal Management System, , , 2025, -. doi: 10.21608/erurj.2025.314637.1178
Mostafa, A., Elsayed, B., Meslhy, E., Omar, N., Khalaf, M., Aboelkhair, M., Elsayed, S., Hesham, R., Hosni, A., Ibrahim, A., Mohsen, B., Mohamed, N., Mohamed, A., Ahmed, M., Mostsfa, N., Ashraf, E., Bataa, A., Elsayed, E., Youssef, M., Amer, A., Sabry, A., Ahmed, S. (2025). 'A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture', EKB Journal Management System, (), pp. -. doi: 10.21608/erurj.2025.314637.1178
Mostafa, A., Elsayed, B., Meslhy, E., Omar, N., Khalaf, M., Aboelkhair, M., Elsayed, S., Hesham, R., Hosni, A., Ibrahim, A., Mohsen, B., Mohamed, N., Mohamed, A., Ahmed, M., Mostsfa, N., Ashraf, E., Bataa, A., Elsayed, E., Youssef, M., Amer, A., Sabry, A., Ahmed, S. A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture. EKB Journal Management System, 2025; (): -. doi: 10.21608/erurj.2025.314637.1178

A Review for the Dual Wavelength Method for Simultaneous Determination of Two Drugs in pharmaceutical Mixture

ERU Research Journal
Articles in Press, Accepted Manuscript, Available Online from 17 February 2025    PDF (839.63 K)
Document Type: Review article
DOI: 10.21608/erurj.2025.314637.1178
Authors
Alaa Ahmed Mostafa* 1; Bassant Elsayed1; Esraa Meslhy1; Nermeen Omar2; Mohamed Khalaf2; Mai Aboelkhair2; Sara Elsayed2; Rawan Hesham2; Abdallah Ahmed Hosni2; Ahmed Mounir Ibrahim2; Basel Mohsen2; Nourhan Mohamed2; Ahmed Mohamed2; Mahmoud Ahmed2; Nada Mostsfa2; Ebtehal Ashraf2; Aya Bataa2; Esraa Elsayed2; Mohamed Youssef2; Ahmed Sheref Amer2; Amira Sabry2; Saad Ahmed2
1Pharmaceutical Analytical Chemistry Department, Faculty Of Pharmacy, Egyptian Russian University, Badr City , Egypt.
2Pharm D pharmacy students, Egyptian Russian University, Badr city, Cairo, Egypt.
Abstract
The dual wavelength method has gained significant attention in pharmaceutical analysis for its efficiency in simultaneous determination of multiple components in a mixture. The dual wavelength approach measures the drug of interest's absorbance values at two wavelengths where the absorbance values of any other medication in the mixture that overlaps with it are equal to zero. This review focuses on the application of the dual wavelength method in the quantitative analysis of two drugs in a mixture. The principles underlying the dual wavelength method, its advantages, challenges, and recent advancements are discussed. Various applications of the dual wavelength method in pharmaceutical analysis, including its use in quality control, pharmacokinetic studies, and formulation analysis, are highlighted. The method was used to determine mixtures as Simeprevir and Sofosbuvir and other mixtures. The method has many advantages such as Enhanced Specificity, Increased Accuracy, Improved Sensitivity and disadvantages such as complexity of calibration, instrumentation eequirements, eotential Interference, limited applicability.
Keywords
Keywords: Dual wavelength; Advantages; Quantitative analysis; Simeprevir; Sofosbuvir
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