Role of Oxidative Stress in Preeclampsia in Egyptian Women
Ahmed, H., Shalaby, H., ElSaid, A., Elkhawaga, O. (2022). Role of Oxidative Stress in Preeclampsia in Egyptian Women. EKB Journal Management System, 56(2), 22-30. doi: 10.21608/mjcc.2022.412106
Hwyda Ahmed; Hend A. Shalaby; Afaf M. ElSaid; OmAli Y Elkhawaga. "Role of Oxidative Stress in Preeclampsia in Egyptian Women". EKB Journal Management System, 56, 2, 2022, 22-30. doi: 10.21608/mjcc.2022.412106
Ahmed, H., Shalaby, H., ElSaid, A., Elkhawaga, O. (2022). 'Role of Oxidative Stress in Preeclampsia in Egyptian Women', EKB Journal Management System, 56(2), pp. 22-30. doi: 10.21608/mjcc.2022.412106
Ahmed, H., Shalaby, H., ElSaid, A., Elkhawaga, O. Role of Oxidative Stress in Preeclampsia in Egyptian Women. EKB Journal Management System, 2022; 56(2): 22-30. doi: 10.21608/mjcc.2022.412106

Role of Oxidative Stress in Preeclampsia in Egyptian Women

Mansoura Journal of Chemistry
Volume 56, Issue 2, April 2022, Page 22-30  XML PDF (1.58 MB)
Document Type: Original Article
DOI: 10.21608/mjcc.2022.412106
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Authors
Hwyda Ahmed* 1; Hend A. Shalaby2; Afaf M. ElSaid3; OmAli Y Elkhawaga4
1Chemistry Department, Faculty of Science, Mansoura University
2Department of Women and obstetrics, Faculty of Medicine, Mansoura University
3Genetic Unit, Department of Pediatrics, Faculty of Medicine, Mansoura University
4, Chemistry Department, Faculty of Science, Mansoura University, Mansoura
Abstract
Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. Preeclampsia (PE) is a multisystem, pregnancy-specific disorder and one of the main causes of fetal and maternal mortality. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state are features of the maternal syndrome. The placenta appears to be the principal source of free radical synthesis but maternal leukocytes and the maternal endothelium are also likely contributors. The aim of this study was to evaluate oxidative stress markers such SOD, GSH, GPx and MDA as well as lipid profile in preeclampsia patient. Egyptian pregnant women (100) were selected for the study which was recruited from Mansoura University Main Hospital, Department of Obstetrics and Gynecology and also 100 normotensive pregnant women were collected. Classified into two groups; patient group with gestational mean age 28.96±6.9 weeks, and gestational age 32.4±3.4 weeks (majority were severe imposed PE) and control group. Our result shows that superoxide dismutase activity and reduced glutathione levels were decreased in preeclamptic women (89.18±19.7 and 0.11±0.08, respectively) when compared to normotensive ones (243.5±23.15 and 1.73±0.365, respectively). On the other hand, malondialdehyde and glutathione peroxidase levels were increased in preeclamptic patient group (0.55±0.11 and 498.56±53.3, respectively) when compared with normalized pregnant ones (0.49±0.25 and 303.22±71.59, respectively). Our finding concluded that preeclampsia pathogenesis is arising from major cascade of oxidative stress that results from the imbalance between oxidant and antioxidant
Keywords
Preeclampsia; Pregnancy; oxidative stress; Hypertensio
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