The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer
Muzaail, H., El-Assmy, A., Harraz, A., Awadalla, A., Shokeir, A., Abdel-Aziz, A. (2022). The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer. EKB Journal Management System, 57(3), 1-5. doi: 10.21608/mjcc.2022.412124
Hazim Hadi Muzaail; Ahmed El-Assmy; Ahmed M. Harraz; Amira Awadalla; Ahmed A. Shokeir; A.F. Abdel-Aziz. "The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer". EKB Journal Management System, 57, 3, 2022, 1-5. doi: 10.21608/mjcc.2022.412124
Muzaail, H., El-Assmy, A., Harraz, A., Awadalla, A., Shokeir, A., Abdel-Aziz, A. (2022). 'The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer', EKB Journal Management System, 57(3), pp. 1-5. doi: 10.21608/mjcc.2022.412124
Muzaail, H., El-Assmy, A., Harraz, A., Awadalla, A., Shokeir, A., Abdel-Aziz, A. The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer. EKB Journal Management System, 2022; 57(3): 1-5. doi: 10.21608/mjcc.2022.412124

The role of vitamin D3 in the recurrence of non-muscle invasive bladder cancer

Mansoura Journal of Chemistry
Volume 57, Issue 3, August 2022, Pages 1-5    PDF (441.38 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2022.412124
Authors
Hazim Hadi Muzaail* 1; Ahmed El-Assmy2; Ahmed M. Harraz3; Amira Awadalla4; Ahmed A. Shokeir4; A.F. Abdel-Aziz1
1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
2Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
4Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Abstract
Aim: To investigate the exact role of vitamin D3, CD68 and CD1-alpha in non-muscle invasive bladder cancer (NMIBC).
 Subjects and Methods: This study including ( 99)  male with non-muscle invasive bladder cancer NMIBC (Ta-T1) who were subjected to transurethral resection (TURBT). As well as control group consists of 50 male individuals. We determined the gene expression level for CD68, CD1-alpha and the protein concentration of vitamin D3 level in blood samples in patients and controls. 
Results: Compared to the control group, vitamin D3 levels were considerably lower in the study group. There was no significant correlation between vitamin D3 with either grade or stage. In comparing the recurrence and non-recurrence groups, vitamin D was significantly increased in non-recurrence group. CD68 was highly expressed in recurrence more than nonrecurrence and control group patient but in case of CD1-alpha gene expression; it was significantly decrease in case of recurrence in a comparison to nonrecurrence and control patients.
Conclusions: The results suggested the possible effect of vitamin D3, CD68 and CD1-alpha in reducing the recurrence status, as presented, CD1-alpha and vitamin D3 were significantly increased in non-recurrence cases; but CD68 was significantly decrease in non- recurrence.
Keywords
non-muscle invasive bladder cancer (NMIBC); vitamin D3, CD68, CD1-alpha
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