Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative
El-Sayed, H., Abd-elattif khalifa, E., El-Gammal, O. (2022). Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative. EKB Journal Management System, 58(4), 1-14. doi: 10.21608/mjcc.2022.412148
H. M. El-Sayed; E. Abd-elattif khalifa; O. A. El-Gammal. "Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative". EKB Journal Management System, 58, 4, 2022, 1-14. doi: 10.21608/mjcc.2022.412148
El-Sayed, H., Abd-elattif khalifa, E., El-Gammal, O. (2022). 'Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative', EKB Journal Management System, 58(4), pp. 1-14. doi: 10.21608/mjcc.2022.412148
El-Sayed, H., Abd-elattif khalifa, E., El-Gammal, O. Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative. EKB Journal Management System, 2022; 58(4): 1-14. doi: 10.21608/mjcc.2022.412148

Synthesis, spectral characterization, DFT and antioxidant and antihomolysis activities of diamagnetic complexes derived from a new hydrazone derivative

Mansoura Journal of Chemistry
Volume 58, Issue 4, December 2022, Page 1-14  XML PDF (1.43 MB)
Document Type: Original Article
DOI: 10.21608/mjcc.2022.412148
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Authors
H. M. El-Sayed* 1; E. Abd-elattif khalifa1; O. A. El-Gammal2
1Faculty of Science, Chemistry Department, Mansoura University, Mansoura
2Faculty of Science, Chemistry Department, Mansoura University
Abstract
Novel series of Zn2+, Cd2+and Hg2+ complexes derived from (E)-2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)-N'-(thiophen-2-ylmethylene)acetohydrazide (HDMAH) in1:1 or 2:1 (L:M) ratio. The complexes were characterized by conventional techniques adopting the molecular formulae; [Zn(HDMAH)2Cl(OH)], [Cd(HDMAH)Cl2H2OEtOH]and[Hg(HDMAH)Cl(OH)EtOH]3EtOH, respectively. Electronic and infrared spectral dataconfirmed the coordination of HDMAH as   neutral ON bidentate in an octahedral environment around metal ion. The structure of Zn+2 was also studied by XRD technique. was completed using the DFT method, which was also utilised to assess other energy properties include electronegativity, HOMO, LUMO, and hardness. As well as using TGA and DrTGA to evaluate thermal stability, Coats-Redfern and Horowitz-Metzger techniques were employed to determine the corresponding thermodynamic parameters of activation. Additionally, each molecule was examined for antioxidant using ABTS+ free radical scavenger and antihemolytic activities. The biological assay is extended to test the inhibition activity of breast cancer. The results revealed Zn+2 possesses a potent activity among all title compounds
Keywords
novel hydrazones; NMR; neutral ON; and antioxidant activity
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