Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats
Wahdan, M., Tolba, E., El-Senduny, F., Elkhawaga, O. (2022). Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats. EKB Journal Management System, 58(4), 15-23. doi: 10.21608/mjcc.2022.412150
Mona Wahdan; Emad Tolba; Fardous F. El-Senduny; Omali Elkhawaga. "Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats". EKB Journal Management System, 58, 4, 2022, 15-23. doi: 10.21608/mjcc.2022.412150
Wahdan, M., Tolba, E., El-Senduny, F., Elkhawaga, O. (2022). 'Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats', EKB Journal Management System, 58(4), pp. 15-23. doi: 10.21608/mjcc.2022.412150
Wahdan, M., Tolba, E., El-Senduny, F., Elkhawaga, O. Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats. EKB Journal Management System, 2022; 58(4): 15-23. doi: 10.21608/mjcc.2022.412150

Effect of βC-loaded silica nanoparticles on L-NAME -induced kidney injury in rats

Mansoura Journal of Chemistry
Volume 58, Issue 4, December 2022, Page 15-23  XML PDF (1.28 MB)
Document Type: Original Article
DOI: 10.21608/mjcc.2022.412150
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Authors
Mona Wahdan* 1; Emad Tolba2; Fardous F. El-Senduny1; Omali Elkhawaga1
1Chemistry Department, Faculty of Science, Mansoura University
2Polymers and Pigments Department, National Research Center, 33 El Bohouth St, Dokki, 12311 Cairo, Egypt.
Abstract
Renal injury (RI) is one of the most main causes of disability and mortality in several countries in the world. RI is caused when the kidneys are damaged and not functioning as they should. Renin-angiotensin-aldosterone system's (RAAS) overactivity, promotes vasoconstriction, hypertension, and renal inflammation. It is linked to the advancement of kidney disease. Herein, we assessed the ameliorative effect of treatment with beta carotene-loaded silica nanoparticles (βC-SiNPs) as a reno-protective agent on renal function and structure using Nω-nitro-L-arginine methyl ester (L-NAME) for induction renal injury in the male rats. Thirty-six rats were divided into six groups: Normal group (N); native beta carotene (N+βC) group; βC-loaded silica nanoparticles (N+βC-SiNPs) group; L-NAME group; L-NAME +βC group and L-NAME + βC-SiNPs group. After L-NAME and/or βC-SiNPs were administrated orally to male rats for 4 weeks, blood samples and kidneys were taken for biochemical analyses and histopathological studies. The obtained results demonstrated that the sol-gel synthesized SiNPs show spherical nanoparticles with average particles size of 290 ± 120 nm. The βc- SiNPs particles also exhibited spherical morphology with average particles size of 460 ± 160nm. βC-SiNPs have a significant reversal effect on kidney function, and markedly improved renal histopathological markers of inflammation and fibrosis.
Keywords
L-NAME; Silica nanoparticles; β-carotene; NOS; RAAS
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