A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines
El-Saudi, A., El-Senduny, F., Shaaban, S., Youssef, M. (2021). A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines. EKB Journal Management System, 52(2), 1-5. doi: 10.21608/mjcc.2021.412191
Abeer M. El-Saudi; Fardous F. El-Senduny; Saad Shaaban; Magdy M. Youssef. "A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines". EKB Journal Management System, 52, 2, 2021, 1-5. doi: 10.21608/mjcc.2021.412191
El-Saudi, A., El-Senduny, F., Shaaban, S., Youssef, M. (2021). 'A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines', EKB Journal Management System, 52(2), pp. 1-5. doi: 10.21608/mjcc.2021.412191
El-Saudi, A., El-Senduny, F., Shaaban, S., Youssef, M. A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines. EKB Journal Management System, 2021; 52(2): 1-5. doi: 10.21608/mjcc.2021.412191

A novel organoselenium compound as antiproliferative agent against ovarian cancer cell lines

Mansoura Journal of Chemistry
Volume 52, Issue 2, May 2021, Page 1-5  XML PDF (968.55 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2021.412191
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Authors
Abeer M. El-Saudi* 1; Fardous F. El-Senduny1; Saad Shaaban2; Magdy M. Youssef3
1Biochemistry Division, Chemistry department, Faculty of Science, Mansoura University, Mansoura, Egypt.
2Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt
3Biochemistry Division, Chemistry department, Faculty of Science, Mansoura University, Mansoura, Egypt
Abstract
Ovarian cancer (OC) is considered a heterogeneous disease usually diagnosed at late stages as there are no symptoms and signs. Hallmarks and heterogeneity of ovarian cancer are limited and hard to establish according to the experiments in vitro models. Surgery, chemotherapy and other traditional treatments are accompanied by many toxic side effects. This study aimed to evaluate the anticancer activity of organoselenium compounds against sensitive cells A2780, cisplatin-resistant cells (A2780CP) and SKOV-3 cells. ((diselanediylbis (4,1-phenylene)) bis (azanediyl)) bis(3-methyl-1-oxobutane-1,2-diyl) diacetate, Compound 16, showed anticancer activity through changing the cell morphology and inhibit cell proliferation and this was confirmed by using MTT (3-(4,5-dimethylthiazoyl)-2,5-diphenyl-tetrazolium bromide(. 
Keywords
Ovarian cancer cells; organoselenium; MTT assay; Proliferation assay
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