Evaluation of the anticancer activity of monoamidinic arylthiophenes | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 48, Issue 2, May 2020, Page 1-5 PDF (729.93 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcc.2020.412871 | ||||
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| Authors | ||||
| Sara A. Al-Shun* 1; Fardous F. El-Senduny1; Mohamed A. Ismail1; Farid A. Badria2; Magdy M. Youssef1 | ||||
| 1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. | ||||
| 2Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt | ||||
| Abstract | ||||
| Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer deaths worldwide. The anticancer drugs being used are losing their effectiveness due to development of anticancer-drug resistance and have severe side effects, poor therapeutic index and high cost. This work was designed to study the anticancer effect of new monocationic arylthiophene derivatives against HCC. The cell viability was initially determined by treating Huh-7 cells with 50 µM concentration of each tested arylthiophene compound. Subsequently, the IC50 values for the most active compounds were determined using MTT assay. The monocationic derivative 2j exhibit the highest cytotoxicity (IC50 = 1.47 ± 0.25 µM) in comparison to the positive control cisplatin (IC50 = 24.9 ± 1.4 µM). The selectivity index of compound 2j (SI = 7.25 ± 0.11) proved the safety to normal lung fibroblast cells (WI-38) vs Huh-7 cells | ||||
| Keywords | ||||
| Hepatocellular carcinoma; cationic compounds; arylthiophenes; cytotoxicity; selectivity index | ||||
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