Synthesis and antimicrobial activity of some new sulfathiazole derivatives
Fadda, A., El-Saadaney, A., Elsayed, E. (2020). Synthesis and antimicrobial activity of some new sulfathiazole derivatives. EKB Journal Management System, 48(2), 6-11. doi: 10.21608/mjcc.2020.412872
Ahmed Ali Fadda; Ahmed Mohamed El-Saadaney; Elsherbiny Hamdy Elsayed. "Synthesis and antimicrobial activity of some new sulfathiazole derivatives". EKB Journal Management System, 48, 2, 2020, 6-11. doi: 10.21608/mjcc.2020.412872
Fadda, A., El-Saadaney, A., Elsayed, E. (2020). 'Synthesis and antimicrobial activity of some new sulfathiazole derivatives', EKB Journal Management System, 48(2), pp. 6-11. doi: 10.21608/mjcc.2020.412872
Fadda, A., El-Saadaney, A., Elsayed, E. Synthesis and antimicrobial activity of some new sulfathiazole derivatives. EKB Journal Management System, 2020; 48(2): 6-11. doi: 10.21608/mjcc.2020.412872

Synthesis and antimicrobial activity of some new sulfathiazole derivatives

Mansoura Journal of Chemistry
Volume 48, Issue 2, May 2020, Page 6-11  XML PDF (739.59 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2020.412872
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Authors
Ahmed Ali Fadda* 1; Ahmed Mohamed El-Saadaney2; Elsherbiny Hamdy Elsayed2
1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt,
2Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt
Abstract
Diazotization of 3,5-diaminopyrazole derivative 2 to form diazonium salt 3, which reacted with either 2-cyano-N-phenylacetamide (4) or  3,5-dimethyl phenol (6) to afford pyrazolo-4,5diazenyl derivatives 5 and 7, respectively. Also, compound 1 was reacted with methyl iodide in potassium carbonate to give N-methyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)carbonohydrazonoyl dicyanide (8), which was treated with hydrazine hydrate to give α-cyanoarylhydrazones 9. Moreover, the reaction of compound 1 with either thiourea or hydroxylamine hydrochloride afforded 4-(2-(4,6-diamino-2-thioxopyrimidin-5(2H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide(10)and4-(2-(3-amino-5-iminoisoxazol-4(5H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide (11), respectively. The newly prepared compounds were selected for their biological evaluation as antimicrobial activities
Keywords
Sulphathiazole; Pyrazole; Pyrimidine; Isoxazole; Antimicrobial activity
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