Synthesis and antimicrobial activity of some new sulfathiazole derivatives | ||
| Mansoura Journal of Chemistry | ||
| Volume 48, Issue 2, May 2020, Pages 6-11 PDF (739.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcc.2020.412872 | ||
| Authors | ||
| Ahmed Ali Fadda* 1; Ahmed Mohamed El-Saadaney2; Elsherbiny Hamdy Elsayed2 | ||
| 1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt, | ||
| 2Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt | ||
| Abstract | ||
| Diazotization of 3,5-diaminopyrazole derivative 2 to form diazonium salt 3, which reacted with either 2-cyano-N-phenylacetamide (4) or 3,5-dimethyl phenol (6) to afford pyrazolo-4,5diazenyl derivatives 5 and 7, respectively. Also, compound 1 was reacted with methyl iodide in potassium carbonate to give N-methyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)carbonohydrazonoyl dicyanide (8), which was treated with hydrazine hydrate to give α-cyanoarylhydrazones 9. Moreover, the reaction of compound 1 with either thiourea or hydroxylamine hydrochloride afforded 4-(2-(4,6-diamino-2-thioxopyrimidin-5(2H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide(10)and4-(2-(3-amino-5-iminoisoxazol-4(5H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide (11), respectively. The newly prepared compounds were selected for their biological evaluation as antimicrobial activities | ||
| Keywords | ||
| Sulphathiazole; Pyrazole; Pyrimidine; Isoxazole; Antimicrobial activity | ||
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