Comparative Clinicopathological Study on the Impact of Intrauterine Infusion of Eugenol Versus Ceftiofur on Experimentally Induced Endometritis in Baladi Female Goats | ||
| New Valley Veterinary Journal | ||
| Volume 5, Issue 2, June 2025, Pages 1-15 PDF (6.4 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/nvvj.2025.350943.1063 | ||
| Authors | ||
| Sara Ahmed Abdelrahman* 1; Sary khalil Abd-Elghaffar2; Waleed Senosy3; Nani Nasreldin4 | ||
| 1Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, New Valley University, El-Kharga, P.O. Box 72511, Egypt. | ||
| 2Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, P.O. Box 71526, Egypt, School of Veterinary Medicine, Badr University in Assiut, Egypt | ||
| 3Theriogenology Department, Faculty of Veterinary Medicine, New Valley University, Al Kharga, P.O. Box 72511, Egypt | ||
| 4Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine. New Valley University, El-Kharga, P.O. Box 72511, Egypt. | ||
| Abstract | ||
| Goats are highly vulnerable to various reproductive disorders including endometritis that adversely affect their productivity and hinder breeding programs. The limitations and side effects of conventional treatments have prompted the research for alternative therapies to treat endometritis. Eugenol, a major component of clove essential oil, is known for its potent anti-inflammatory and antioxidant properties. This study aimed to evaluate the efficacy of eugenol as an alternative to ceftiofur for treating experimentally induced endometritis in female goats by assessing selected clinicopathological parameters. Twenty pluriparus Balady (n=20) female goats were assigned into four equal groups, each comprising five goats. Estrus synchronization was achieved using synthetic prostaglandin to ensure all goats had the same luteal phase. The control group (Control) received 3 ml of normal saline, while the remaining three groups underwent experimental induction of endometritis via intrauterine infusion of 3 ml of 95% ethanol. Among these, the endometritis group (ENM) received no treatment. The (ENM+EGL) group was treated with 3 ml of eugenol (16 mg/ml, single dose), and the (ENM+CEF) group was treated with 3 ml of ceftiofur (125 mg, single dose). Blood samples were collected two weeks post-induction to evaluate the leukogram profile, serum biochemical variables, oxidative stress, and antioxidant biomarkers. Results indicated significant increases in the serum concentration of ALT, AST, SDH, urea, creatinine, and H2O2, alongside SOD, total protein, albumin, and globulin were reduced considerably. The histopathological findings revealed severe lesions in the endometrium of affected does. Both eugenol and ceftiofur mitigated these changes, although ceftiofur demonstrated superior efficacy. | ||
| Keywords | ||
| Endometritis; Eugenol; Ceftiofur; Female goats | ||
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