Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells
Altouhamy, M., El-Senduny, F., Shaaban, S., El-Khawaga, O. (2020). Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells. EKB Journal Management System, 50(4), 26-30. doi: 10.21608/mjcc.2020.412957
Miram Altouhamy; Fardous F. El-Senduny; Saad Shaaban; Omali El-Khawaga. "Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells". EKB Journal Management System, 50, 4, 2020, 26-30. doi: 10.21608/mjcc.2020.412957
Altouhamy, M., El-Senduny, F., Shaaban, S., El-Khawaga, O. (2020). 'Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells', EKB Journal Management System, 50(4), pp. 26-30. doi: 10.21608/mjcc.2020.412957
Altouhamy, M., El-Senduny, F., Shaaban, S., El-Khawaga, O. Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells. EKB Journal Management System, 2020; 50(4): 26-30. doi: 10.21608/mjcc.2020.412957

Cytotoxicity of 1-(3, 5- bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea against Triple Negative Breast Cancer Cells

Mansoura Journal of Chemistry
Volume 50, Issue 4, December 2020, Page 26-30  XML PDF (701.79 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2020.412957
View on SCiNiTO View on SCiNiTO
Authors
Miram Altouhamy* 1; Fardous F. El-Senduny2; Saad Shaaban3; Omali El-Khawaga4
1M.Sc. student, biochemistry division, chemistry department, faculty of science, Mansoura University
2Lecturer of Biochemistry, Faculty of Science, Chemistry department, Mansoura University
3Associate Professor of Organic Chemistry, Chemistry Department, Faculty of Science, Mansoura University
4Professor of Biochemistry, Faculty of Science, Chemistry department, Mansoura University
Abstract
Breast cancer is a major cause of death associated with cancer in women each year. Triple-negative breast cancer (TNBC) is considered as a subtype of breast cancer representing about 15% of breast cancer. It is not yet certain whether the poor prognosis of TNBC is due to the aggressive behavior or because of the lack of the targeted therapy. These malignant tumors pose a major health problem and targeting these tumors with traditional chemotherapy cannot be the only treatment as it has serious side effects. Accordingly, the present study aimed to evaluate the in vitro anticancer activity of organoselenium compounds against MDA-MB-231 and 4T1 TNBC cell lines. Compared with commercial anticancer drug cisplatin, 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea showed anticancer action. Additionally, the inhibition activities were dose and time dependent as measured by MTT assay. These results suggest that the toxicity induced by 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-selenocyanatophenyl) urea might be efficient in the management of TNBC by utilizing several therapeutic approaches lowering the side effects related to existing TNBC treatments
Keywords
Triple negative breast cancer; organoselenium; cytotoxicity; MTT assay; Proliferation
Statistics
Article View: 95
PDF Download: 16