Short Telomeres and Survival Rate in Bone Marrow Failure Disease
El-Dahshan, Z., El-Naggar, M., El-Waseef, A., Zaghloul, H., Darwish, A., Mabed, M., Abd El-Aziz, S., Abdel-Ghaffar, H. (2019). Short Telomeres and Survival Rate in Bone Marrow Failure Disease. EKB Journal Management System, 43(1), 1-6. doi: 10.21608/mjcc.2019.412959
Zainab El-Dahshan; Mohammed El-Naggar; Ahmed El-Waseef; Hosam Zaghloul; Ahmad Darwish; Mohamed Mabed; Sherin Abd El-Aziz; Hasan Abdel-Ghaffar. "Short Telomeres and Survival Rate in Bone Marrow Failure Disease". EKB Journal Management System, 43, 1, 2019, 1-6. doi: 10.21608/mjcc.2019.412959
El-Dahshan, Z., El-Naggar, M., El-Waseef, A., Zaghloul, H., Darwish, A., Mabed, M., Abd El-Aziz, S., Abdel-Ghaffar, H. (2019). 'Short Telomeres and Survival Rate in Bone Marrow Failure Disease', EKB Journal Management System, 43(1), pp. 1-6. doi: 10.21608/mjcc.2019.412959
El-Dahshan, Z., El-Naggar, M., El-Waseef, A., Zaghloul, H., Darwish, A., Mabed, M., Abd El-Aziz, S., Abdel-Ghaffar, H. Short Telomeres and Survival Rate in Bone Marrow Failure Disease. EKB Journal Management System, 2019; 43(1): 1-6. doi: 10.21608/mjcc.2019.412959

Short Telomeres and Survival Rate in Bone Marrow Failure Disease

Mansoura Journal of Chemistry
Volume 43, Issue 1, February 2019, Page 1-6  XML PDF (878.54 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2019.412959
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Authors
Zainab El-Dahshan* 1; Mohammed El-Naggar1; Ahmed El-Waseef1; Hosam Zaghloul2; Ahmad Darwish3; Mohamed Mabed4; Sherin Abd El-Aziz5; Hasan Abdel-Ghaffar5
1Chemistry Department, Biochemistry Division, Faculty of Science, Mansoura University, Egypt
2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
3Pediatric Department, Children's Hospital, Faculty of Medicine, Mansoura University, Egypt
4Oncology Center, Faculty of Medicine, Mansoura University, Egypt.
5Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt
Abstract
Bone marrow failure (BMF) syndromes include inherited and acquired conditions. Inherited bone marrow failure includes a number of syndromes; with Fanconi anemia (FA) being the most common one of them. Telomeres became shorter with each cell division, but in hematopoietic stem cell, maintenance of their length is mediated by telomerase. Short telomeres lead to instability of cell function where diseases occur. BMF might be developed as a result of low telomerase activity or short telomeres. So, our study aims to assess the relative telomere length (RTL) and its correlation with gender of the Egyptian patients with BMF syndromes for overall survival and patient's current situation. The study included 39 BMF patients and 15 individuals as a healthy control group. The RTL is evaluated for them using Real-Time Quantitative-Polymerase Chain Reaction (RQ-PCR) technique. We observed that there was no difference in the RTL between males and females (P-value= 0.921). Kaplan–Meier survival analysis showed that there was no difference in the survival rate of BMF patients (P-value=0.695). We conclude that the death or mortality rate is not associated with short telomeres in BMF patients either in males or females.
Keywords
Telomere length; Telomerase; Telomere shortening; Bone Marrow Failure; real-time quantitative PCR (RQ-PCR); Survival rate; Mortality
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