Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon
Kandil, E., Mekabaty, A., Shaker, N., Musbah, T. (2020). Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon. EKB Journal Management System, 44(2), 8-13. doi: 10.21608/mjcc.2020.412970
E. M. Kandil; Ahmed Mekabaty; Noha Shaker; Tajdida-imhimmed Musbah. "Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon". EKB Journal Management System, 44, 2, 2020, 8-13. doi: 10.21608/mjcc.2020.412970
Kandil, E., Mekabaty, A., Shaker, N., Musbah, T. (2020). 'Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon', EKB Journal Management System, 44(2), pp. 8-13. doi: 10.21608/mjcc.2020.412970
Kandil, E., Mekabaty, A., Shaker, N., Musbah, T. Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon. EKB Journal Management System, 2020; 44(2): 8-13. doi: 10.21608/mjcc.2020.412970

Synthesis and antioxidant evaluation of pyrazolyl-imidazolone analogues utilizing 4-((1,3-diphenyl-1h-pyrazol-4-yl)methylene)-2-phenyl-1,3-oxazol-5(4h)-one synthon

Mansoura Journal of Chemistry
Volume 44, Issue 2, May 2020, Pages 8-13    PDF (1.27 M)
Document Type: Original Article
DOI: 10.21608/mjcc.2020.412970
Authors
E. M. Kandil1; Ahmed Mekabaty* 2; Noha Shaker1; Tajdida-imhimmed Musbah1
1Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, ET-35516 Mansoura, Egypt
2Chemistry Department, Faculty of Science, Mansoura University
Abstract
A new series of pyrazolyl-imidazolone derivatives 3-6 were synthesized via the reaction of the readily obtainable pyrazolyl-oxazol-5(4H)-one 2 with various aromatic amines namely, 4-aminophenol, ethyl 4-aminobenzoate, 4-aminoacetophenone and 2-aminobenzoic acid in acetic acid including freshly melted sodium acetate. Furthermore, the pyrazolyl-imidazolone 3 on reaction with ethyl 2-chloroacetate, acetic anhydride, benzoyl chloride or benzenesulfonyl chloride afforded the corresponding pyrazolyl-imidazolone derivatives 7-10. The novel compounds were characterized by spectral data and elemental analysis and measured as antioxidant agents using ABTS assay. The candidates showed moderate to good activity compared to ascorbic acid.
Keywords
Oxazolones; imidazolones; pyrazole; 4-aminoacetophenone; antioxidant activity
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