Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety
Mekabaty, A., . Fouda, A., . I. Shaaban, I. (2019). Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety. EKB Journal Management System, 46(4), 7-11. doi: 10.21608/mjcc.2019.413044
Ahmed Mekabaty; A. S . Fouda; Ibrahim E . I. Shaaban. "Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety". EKB Journal Management System, 46, 4, 2019, 7-11. doi: 10.21608/mjcc.2019.413044
Mekabaty, A., . Fouda, A., . I. Shaaban, I. (2019). 'Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety', EKB Journal Management System, 46(4), pp. 7-11. doi: 10.21608/mjcc.2019.413044
Mekabaty, A., . Fouda, A., . I. Shaaban, I. Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety. EKB Journal Management System, 2019; 46(4): 7-11. doi: 10.21608/mjcc.2019.413044

Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety

Mansoura Journal of Chemistry
Volume 46, Issue 4, December 2019, Pages 7-11    PDF (908.67 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2019.413044
Authors
Ahmed Mekabaty* 1; A. S . Fouda2; Ibrahim E . I. Shaaban2
1Chemistry Department, Faculty of Science, Mansoura University
2Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, ET-35516 Mansoura, Egypt
Abstract
In the present study, 2-amino-4-methyl-5-(pyridin-2-ylcarbamoyl)thiophene-3-ethylcarboxylate (2) has been achieved using Gewald’s methodology between 3-oxo-N-(pyridin-2-yl)butanamide (1), ethyl 2-cyanoacetate and elemental sulfur in refluxing ethyl alcohol containing a catalytic amount of morpholine. This 2-aminothiophene derivative was served as key synthon for the synthesis of new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives via its reactions with the convenient chemical reagents. The mechanistic aspects for the achievement of the new thiophene derivatives were also discussed
Keywords
Thiophene; thiazolidinone; chromene; pyrrolone; Gewald’s methodology
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