synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus | ||||
Mansoura Journal of Chemistry | ||||
Volume 46, Issue 4, December 2019, Page 16-21 PDF (899.9 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjcc.2019.413046 | ||||
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Authors | ||||
Elsherbiny Hamdy El-Sayed* 1; Ahmed Ali Fadda2; Ahmed Mohamed El-Saadaney3 | ||||
1Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt | ||||
2Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt | ||||
3Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt, | ||||
Abstract | ||||
Treatment of 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)-N-(thiazol-2-yl)benzenesulfonamide (1) with malononitrile, 2-(ethoxymethylene)malononitrile, ethyl 2-cyano-3-ethoxyacrylate and diethyl 2-(ethoxymethylene)malonate afforded pyrazolo[1,5-a]pyrimidine derivatives 2-5. Also, compound 1 was react with ethyl 3,5-diphenylcyclohexanone-2-acetate (6) afford pyrazolo[5,1-b]quinazoline derivative 7. Moreover, the reaction of aminopyrazole 1 with enaminones 8, 10 in glacial acetic acid gave pyrazolo[1,5-a]pyrimidine derivative 9 and pyrazolo[1,5-a]quinazoline derivative 11. Furthermore, the reaction of aminopyrazole 1 with enaminonitriles 12, 14 gave pyrazolo[1,5-a]pyrimidine derivatives 13 and 15, respectively. The newly prepared compounds were screened for their biological evaluation as antimicrobial activities. | ||||
Keywords | ||||
Sulphathiazole; Benzenesulfonamide; Pyrazolopyrimidine; Biological activity | ||||
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