synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus
El-Sayed, E., Fadda, A., El-Saadaney, A. (2019). synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus. EKB Journal Management System, 46(4), 16-21. doi: 10.21608/mjcc.2019.413046
Elsherbiny Hamdy El-Sayed; Ahmed Ali Fadda; Ahmed Mohamed El-Saadaney. "synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus". EKB Journal Management System, 46, 4, 2019, 16-21. doi: 10.21608/mjcc.2019.413046
El-Sayed, E., Fadda, A., El-Saadaney, A. (2019). 'synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus', EKB Journal Management System, 46(4), pp. 16-21. doi: 10.21608/mjcc.2019.413046
El-Sayed, E., Fadda, A., El-Saadaney, A. synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus. EKB Journal Management System, 2019; 46(4): 16-21. doi: 10.21608/mjcc.2019.413046

synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus

Mansoura Journal of Chemistry
Volume 46, Issue 4, December 2019, Pages 16-21    PDF (899.9 K)
Document Type: Original Article
DOI: 10.21608/mjcc.2019.413046
Authors
Elsherbiny Hamdy El-Sayed* 1; Ahmed Ali Fadda2; Ahmed Mohamed El-Saadaney3
1Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt
2Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
3Department of Chemistry, Faculty of Science, Port Said University, 42526 Port Said, Egypt,
Abstract
Treatment of 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)-N-(thiazol-2-yl)benzenesulfonamide (1) with malononitrile, 2-(ethoxymethylene)malononitrile, ethyl 2-cyano-3-ethoxyacrylate and diethyl 2-(ethoxymethylene)malonate afforded pyrazolo[1,5-a]pyrimidine derivatives 2-5. Also, compound 1 was react with ethyl 3,5-diphenylcyclohexanone-2-acetate (6) afford pyrazolo[5,1-b]quinazoline derivative 7. Moreover, the reaction of aminopyrazole 1 with enaminones 8, 10 in glacial acetic acid gave pyrazolo[1,5-a]pyrimidine derivative 9 and pyrazolo[1,5-a]quinazoline derivative 11. Furthermore, the reaction of aminopyrazole 1 with enaminonitriles 12, 14 gave pyrazolo[1,5-a]pyrimidine derivatives 13 and 15, respectively. The newly prepared compounds were screened for their biological evaluation as antimicrobial activities.
Keywords
Sulphathiazole; Benzenesulfonamide; Pyrazolopyrimidine; Biological activity
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