Comparative Study of Influence of General Anaesthesia Alone versus General Anaesthesia with Magnesium Sulfate on Post-Operative Inflammatory Biomarkers after Elective Abdominal Hysterectomy | ||||
| Benha Journal of Applied Sciences | ||||
| Volume 9, Issue 11, November 2024, Page 15-21 PDF (339.29 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2024.332228.1529 | ||||
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| Authors | ||||
Ehab Ahmed Abd El-Rahman1; Ehab Elshahat Afifi2; Dina Elbarbary3; Mostafa Mahmoud Ahmed  4
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| 1Professor of Anesthesiology& I.C.U, Faculty of Medicine - Benha University | ||||
| 2Professor of anesthesia and Intensive care Faculty of Medicine - Benha University | ||||
| 3Assistant Professor of Anaesthesia and ICU, Faculty of Medicine, Benha University | ||||
| 4(Master degree in anaesthesia, Ain shams university, 2015) | ||||
| Abstract | ||||
| Background: As the second most common intracellular cation, behind potassium, enzyme activities in humans depend on magnesium. This study examined the effects of three blood inflammatory biomarkers—C-reactive protein, interleukin 6, and procalcitonin—after an elective abdominal hysterectomy between a general anesthetic alone and a general anesthesia supplemented with magnesium sulphate. Methods: This randomized controlled study included forty patients who chose to have a general anesthesia for their abdominal hysterectomy. Group 1 patients were all given general anesthesia. Under the influence of general anesthesia, patients in Group 2 received magnesium sulfate. There was a significant difference in IL6 levels between the groups given general anesthesia and those given MgSO4 at 1 and 4 hours postoperatively (P value < 0.001). On the first and fourth hours after surgery, the procalcitonin levels of the MgSO4 group were noticeably lower than those of the general anesthetic group (p < 0.001, respectively). Furthermore, the MgSO4 group showed a significantly reduced CRP level four hours after the procedure, in contrast to the group that had general anesthesia (P value < 0.001). In all groups, there was a link between the level of interleukin-6 at 4 hours and the duration of the surgical procedure (p value 0.001 and <0.001 in group I and group II respectively), indicating that the surgery may have been more complex. End result: When magnesium sulphate was administered in addition to general anesthesia after an elective abdominal hysterectomy and procalcitonin were much lower than when general anesthetic was administered alone. | ||||
| Keywords | ||||
| General anesthesia; magnesium sulfate; and inflammatory biomarkers are all things that are linked to elective hysterectomy | ||||
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