Serum Interleukin 40 and Transforming Growth Factor -β in patients with inflammatory acne: a narrative review | ||||
| Benha Journal of Applied Sciences | ||||
| Volume 9, Issue 12, December 2024, Page 59-62 PDF (285.92 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2025.344024.1554 | ||||
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| Authors | ||||
Karem Taha Ibrahim Khalil1; Ahmed Mohammed Hamed2; Samar Ahmed Abd El-Hamid Abd El-Latif  3; Enas Sebaey Ahmed4
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| 1Assistant Professor of Dermatology & Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt | ||||
| 2Professor of Dermatology & Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt | ||||
| 3M.B.B.Ch, Faculty of Medicine, Benha University, 2017, Benha, Egypt | ||||
| 4Assistant Professor of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt | ||||
| Abstract | ||||
| Background: Numerous pathogenic factors contribute to the inflammatory nature of acne vulgaris, a prevalent skin condition. Acne lesion genesis and the function of skin immune cells are poorly understood. Objectives: The objective of the research was to gain insight into the immunologic alterations that occur during acne progression by measuring serum IL-40 and TGF-β levels. Data Sources: Through the use of Medline databases (Pub Med and Medscape) and research on the function of IL-40 and TGF-β in acne sufferers up to the year 2024. Study Selection: The inclusion of all research was determined by separate evaluations. They were considered for inclusion if they met the following requirements: 1. The publication is in English. Second, they are published in publications that undergo a peer review process.3. Evaluate the function of IL-40 or TGFβ in individuals suffering from acne vulgaris. Data Extraction: Research was not considered for inclusion if it did not meet certain requirements. Ethical permission, clearly stated eligibility criteria, suitable controls, sufficient information, and well-defined evaluation methods were all factors in determining the study's quality. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form. Conclusions: TGF-β and IL-40 have a crucial role in the development of acne vulgaris and may serve as a predictor of acne. | ||||
| Keywords | ||||
| Acne vulgaris; Transforming growth factor-β; Interleukin 40 | ||||
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