GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract
Ramadan, A., EL–Sheikh, H., Shehata, R., Al-Bedak, O. (2025). GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract. EKB Journal Management System, 10(1), 1-14. doi: 10.21608/mb.2024.317224.1165
Ahmed M. A. A. Ramadan; Hussein H. EL–Sheikh; Reda M. Shehata; Osama A. M. Al-Bedak. "GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract". EKB Journal Management System, 10, 1, 2025, 1-14. doi: 10.21608/mb.2024.317224.1165
Ramadan, A., EL–Sheikh, H., Shehata, R., Al-Bedak, O. (2025). 'GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract', EKB Journal Management System, 10(1), pp. 1-14. doi: 10.21608/mb.2024.317224.1165
Ramadan, A., EL–Sheikh, H., Shehata, R., Al-Bedak, O. GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract. EKB Journal Management System, 2025; 10(1): 1-14. doi: 10.21608/mb.2024.317224.1165

GC-MS, antibacterial, antibiofilm, and anticancer properties against MCF–7 and HEPG2 cell lines of Aspergillus terreus AUMC 15762’ crude extract

Microbial Biosystems
Article 2, Volume 10, Issue 1, March 2025, Page 1-14  XML PDF (937.23 K)
Document Type: Original Article
DOI: 10.21608/mb.2024.317224.1165
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Authors
Ahmed M. A. A. Ramadanorcid 1; Hussein H. EL–Sheikh1; Reda M. Shehata1; Osama A. M. Al-Bedak email orcid 2, 3
1Department of Botany and Microbiology, Faculty of Science, Al Azhar University, Cairo, 11511, Egypt.
2Assiut University Mycological Centre, Assiut 71511, Egypt.
3ERU Science and Innovation Center of Excellence, Egyptian Russian University, Badr city 11829, Egypt,
Abstract
In this investigation, GC-MS analysis was used to assess the chemical composition of the aqueous crude extract generated by A. terreus AUMC 15762 in a liquid medium. There were twenty-five identified chemical components in the crude extract, including fatty acids, monosaccharide derivatives, tertiary amines, alkaloids, ethylbenzenes, polyethylene oxides, Phenolic derivatives, furan derivatives, pyranones derivatives, oxygenated hydrocarbons, and halogenated alcohol. A. terreus crude extract at 20, 10, 5, and 2.5 mg/mL has demonstrated suppression of Escherichia coli, Serratia marcescens, Staphylococcus aureus, and Staphylococcus epidermidis, respectively. Inhibition zones against the bacterial strains were shown to be 20±1, 18±2, 19±2, and 20±1 mm at 2.5 mg/mL. Antibiofilm capability was demonstrated by 92.69, 92.00, 93.46, and 88.17 %, against E. coli, S. marcescens, S. aureus, and S. epidermidis, respectively. Moreover, the crude extract of A. terreus has exhibited a noteworthy cytotoxic reaction against the human breast carcinoma cells (MCF–7) and human hepatocarcinoma cell lines (HepG2), with IC50 values of 156.84±2.15 µg/mL and 120.59±1.96 µg/mL, respectively. The objective of this research is to examine the chemical profile that was extracted using aqueous from A. terreus AUMC 15762 and determine its antibacterial, antibiofilm, and anticancer properties.
Keywords
Alkaloids; antioxidants; chemopreventive properties; ethylbenzenes; fatty acids; furan derivatives; polyethylene oxides
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