Atrial Fibrillation as an independent risk factor for CKD progression | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 35, Volume 8, Issue 1, January 2025, Page 417-430 PDF (301.69 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2025.352103.2077 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noher M. Abass   1; Marwa Abdelhady2; Mohamed H. El-Rashidy 3
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| 1Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Luxor University, Luxor, Egypt. | ||||
| 3Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| Abstract | ||||
| Background: Atrial fibrillation (AF) and chronic kidney disease (CKD) often occur together. However, the specific impact of AF on the progression of kidney function decline in CKD patients is not fully understood. Objectives: This work aimed to assess the relationship between AF and the decline in kidney function in patients with CKD. Patients and methods: A cross-sectional work had been performed, involving 300 CKD patients, who had been allocated into two groups: patients with AF (n=150) and patients without AF (n=150). Demographic, clinical, and laboratory data were gathered, Renal function decline was assessed based on reductions in eGFR of ≥20%, ≥30%, ≥40%, or ≥50% throughout the study follow-up period. Results: patients with AF experienced substantially greater declines in eGFR compared to patients without AF (34.0% vs. 8.7% for ≥20% decline, p < 0.001). The AF group also revealed greater rates of progression to end-stage renal disease (7.3% vs. 2.7%, p = 0.064). additionally, the mortality rate in the AF group had been greater contrasted to in the non-AF group (4.7% vs. 1.3%, p = 0.092). Greater reductions in eGFR substantially elevated the risk of AF, with declines of ≥20%, ≥30%, ≥40%, and ≥50% associated with progressively higher odds ratios (ORs) for AF, that ranges from 1.490 to 4.950 (all p < 0.001). The CHA2DS2-VASc score had been substantially elevated in the AF group. Conclusion: Atrial fibrillation is linked to accelerated renal function decline and increased mortality in patients with CKD. | ||||
| Keywords | ||||
| Atrial fibrillation; Chronic kidney disease; End-stage renal disease; Mortality; CHA2DS2-VASc score | ||||
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