Efficacy of Non-Invasive Vagus Nerve Stimulation for Depression in Elderly | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 129, Volume 98, Issue 1, January 2025, Pages 897-904 PDF (431.18 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2025.413757 | ||
| Abstract | ||
| Background: Depression is one of the common mental illnesses affecting over 300 million subjects all over the world and has been considered a main cause of disability in recent years. Objective: To investigate the effect of non-invasive vagus nerve stimulation (NVNS) for depression in elderly. Patients and Methods Forty patients diagnosed with depression; their age 60-70 years old. They were selected according to inclusion criteria from Matareya Teaching Hospital and were divided into two groups equal in number Group < strong> A (Study group): Twenty (20) patients received vagus nerve stimulation as adjuvant to standard medical treatment and psychotherapy. Group < strong> B (Control group): Twenty (20) patients receivedstandard care for major depressive disorder (MDD) patients in the form of medical treatment and psychotherapy. Results: There was statistically significant difference between two groups in the form of improvement the Hamilton Depression Rating Scale post treatment for group A and laboratory results of C-reactive protein (CRP), pro-inflammatory interleukin (IL)-6, IL-1, tumor necrosis factor-alpha (TNF-α), Serotonin post-treatment for group A in comparison to other group who did not receive non-invasive vagus nerve stimulation. Conclusion: Use of NVNS for elderly patients with depression is an effective additional adjuvant intervention to alleviate symptoms and reduce the severity of the disease. | ||
| Keywords | ||
| Depression; NVNS; the HAMD; TNF-α; Interleukin | ||
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