Trimethoprim drug derivatives: A review of synthesis, metal complexes, nanoparticles, and biological activity | ||||
| Frontiers in Scientific Research and Technology | ||||
| Volume 10, Issue 1, February 2025 PDF (878.54 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/fsrt.2025.353037.1147 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hossam H Nasrallah   1; Adel S. Orabi2; Abbas M. Abbas3; Ahmed Aboelmagd3
| ||||
| 1Sinai university, Suez canal university, | ||||
| 2Chemistry department, Faculty of Science, Suez Canal University, Ismailia, Egypt | ||||
| 3Chemistry, Faculty of science, Suez Canal | ||||
| Abstract | ||||
| Trimethoprim is currently often utilized in modern medicine due to its organic features. Trimethoprim inhibits vulnerable organisms from converting dihydrofolate to tetrahydrofolate, which is the active form of Folic acid. We report on many Trimethoprim derivatives and their complexes were characterized using various spectroscopic techniques, including X-ray diffraction, infrared, and ultraviolet-visible measurements. In this review, the pharmacological properties and molecular mechanism of TMP in recent years are discussed. Trimethoprim derivatives are created when their molecular composition is modified, increasing the probability that they will bind to proteins. Trimethoprim is a bridging bidentate ligand that can bind to metal ions via its amino groups and pyrimidine rings. This review outlines a decade of study on the biological properties of trimethoprim derivatives. Trimethoprim derivatives have been shown to exhibit several biological characteristics throughout the last few decades. With great therapeutic results, it has been utilized to treat a wide range of diseases. Therefore, it is a promising drug with a lot of scope for study. | ||||
| Keywords | ||||
| Trimethoprim; antimicrobial; anticancer; metal complex | ||||
|
Statistics Article View: 207 PDF Download: 263 |
||||
