Therapeutic efficacy of targeted paclitaxel loaded on albumin nanoparticles on DMBA induced oral squamous cell carcinoma | ||||
| Al-Azhar Journal of Dental Science | ||||
| Volume 28, Issue 1, January 2025, Page 71-80 PDF (2.08 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajdsm.2023.222776.1441 | ||||
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| Authors | ||||
AbdElhamid Elzarka  1; Amr Saad Abd Al-Wahab2; mohamed mahmoud ahmed3
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| 1Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys- Cairo), Al-Azhar University, Egypt | ||||
| 2Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys-Cairo), Al-Azhar University, Egypt4. | ||||
| 3Oral and Dental Pathology Department, Faculty of Dental Medicine (Boys-Cairo), Al-Azhar University, Egypt. | ||||
| Abstract | ||||
| Purpose: This research was aimed to determine therapeutic efficacy of targeted paclitaxel loaded on albumin nanoparticles on DMBA induced oral squamous cell carcinoma (OSCC). Subjects & methods: The thirty Syrian male hamsters had been separated into three groups, each with 10 members, that had been all equal. GI: To serve as negative controls, animals were left untreated. For fourteen weeks, seven,twelve-dimethylbenz (a) anthracene was applied 3 times per week to right pouches of animals in groups GII and GIII. In GII: No additional therapy had been administered. Whilst animals in GIII had been injected intraperitoneally (IP) with nanoparticles ab blbumin bound (NAB) paclitaxel (PTX) (ten mg/kg) two times per week for2 weeks. After termination of experiment, gross observations had been recorded. Then, animals had been euthanized, all pouches had been surgically excised, fixed, & processed for hematoxylin & eosin stain examination & immunohistochemical staining utilizing (BCL2) as anti-apoptotic marker. Results: In this research, outcomes discovered some variability across medicated G (GIII)contrasted toGII. IHC of BCL2 highly revealed variation among GI & GII as well as GII & GIII (p value < 0.001). Conclusion: Conjugation of folate on surface of NAB improved cellular uptake, infiltration, & blood brain barrier penetration. folate modified NAB had been confirmed to be more efficient to induce apoptosis of OSSC with encapsulation of PTX. | ||||
| Keywords | ||||
| HBP carcinoma; paclitaxel; albumin nanoparticles; apoptosis | ||||
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