Novel biosynthesis of manganese dioxide nanoparticles using watermelon peel extract and their biological applications | ||
| Microbial Biosystems | ||
| Volume 10, Issue 1, March 2025, Pages 112-122 PDF (785.77 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mb.2025.314779.1155 | ||
| Authors | ||
| Rakan A. Hussein* 1; Fatema W. Abdul Aziz1; Hala H. Al-Haideri2; Safaa A. S. Al-Qaysi2 | ||
| 1Department of Biology, College of Education for Women, University of Kirkuk, Iraq. | ||
| 2Department of Biology, College of Science for Women, University of Baghdad, Iraq. | ||
| Abstract | ||
| This work was the first to apply a green and environmentally acceptable technique to produce manganese dioxide nanoparticles (MnO2NPs) using watermelon peel extract (WPE). FTIR, XRD, UV-visible, and TEM were all used to completely characterize the biosynthesized MnO2NPs. MnO2NPs were produced and found to have a polycrystalline crystal structure with a mean particle size of 8 nm, according to their characterization. With MICs, or minimum inhibitory concentrations, of 400, 100, 100, and 200 µg/mL against S. aureus, B. subtilis, E. coli, and P. aeruginosa, MnO2NPs have demonstrated intriguing antibacterial effectiveness, correlating with the antimicrobial results. MnO2NPs also show excellent antibiofilm action against MRSA in a dose-dependent manner. Furthermore, MnO2NPs have high antioxidant activity; the DPPH technique yielded an IC50 of 218 µg/mL. MnO2NPs may also have anticancer properties against the MCF7 malignant cell IC50 was 366 µg/mL and 74% and 93% suppression percentages at 1000 and 500 µg/mL, respectively. In conclusion, watermelon peel material was used to biosynthesize MnO2NPs, which exhibit strong antibacterial, antibiofilm, anticancer, and antioxidant properties. | ||
| Keywords | ||
| Antibacterial; antibiofilm; anticancer; antioxidant; green synthesis; MnO2NPs | ||
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