INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS
El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. (2025). INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS. EKB Journal Management System, 6(1), 111-122. doi: 10.21608/dsu.2025.315963.1254
Mai Osman El-Halwagy; Enas Mahmoud Hegazy; Hany Kamel Shalaby; Elham Fathy Mahmoud. "INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS". EKB Journal Management System, 6, 1, 2025, 111-122. doi: 10.21608/dsu.2025.315963.1254
El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. (2025). 'INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS', EKB Journal Management System, 6(1), pp. 111-122. doi: 10.21608/dsu.2025.315963.1254
El-Halwagy, M., Hegazy, E., Shalaby, H., Mahmoud, E. INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS. EKB Journal Management System, 2025; 6(1): 111-122. doi: 10.21608/dsu.2025.315963.1254

INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS

Dental Science Updates
Article 13, Volume 6, Issue 1, March 2025, Page 111-122  XML PDF (2.48 MB)
Document Type: Original Article
DOI: 10.21608/dsu.2025.315963.1254
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Authors
Mai Osman El-Halwagy email orcid 1; Enas Mahmoud Hegazyorcid 2; Hany Kamel Shalaby3; Elham Fathy Mahmoud2
1Oral Biology Department, Faculty of Dentistry, Suez University, Suez, Egypt.
2Oral Biology Department, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
3Oral Medicine and Periodontology Department, Faculty of Dentistry, Suez University, Suez, Egypt.
Abstract
Introduction: Osteoporosis is a bone disorder with significant alterations in bone
biologic material and consequent bone structural distraction. Low-level laser therapy
(LLLT) has been studied as a physical modality that influences cellular activity through
photochemical, photophysical, and photobiological mechanisms, making it an effective
intervention for osteoporosis. Aim of the study: The current study was conducted to
evaluate the impacts of low-level laser therapy on glucocorticoid induced osteoporosis
at different time intervals. Methodology: This investigation involved 40 adult male
albino rats, which were evenly distributed into four groups, each containing ten rats;
control, DEX, 7 days LLLT, and 25 days LLLT. At the end of the experiment, all the
rats were humanely euthanized. Their lower jaws were then collected and subjected to
staining with Hematoxylin & Eosin (H&E) and immunohistochemical (IHC) analysis
for RANKL and OPG. Results: DEX group revealed massive alveolar bone destruction
with strong RANKL and weak OPG immunoreactivities. However, 7 days LLLT and
25 days LLLT groups showed improvements in the alveolar bone architecture with
decreased RANKL and increased OPG immunoreactivities. Conclusion: Through
RANKL/OPG ratio downregulation, LLLT improved bone architecture, encouraged
bone healing, and stimulated osteogenesis over time.
Keywords
Glucocorticoid; Immunohistochemical; Low-Level Laser Therapy; Osteoporosis
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