INFLUENCE OF LOW-LEVEL LASER THERAPY ON RANKL AND OPG LEVEL IN ALVEOLAR BONE OF OSTEOPOROTIC RATS | ||
| Dental Science Updates | ||
| Article 13, Volume 6, Issue 1, March 2025, Pages 111-122 PDF (2.48 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/dsu.2025.315963.1254 | ||
| Authors | ||
| Mai Osman El-Halwagy* 1; Enas Mahmoud Hegazy2; Hany Kamel Shalaby3; Elham Fathy Mahmoud2 | ||
| 1Oral Biology Department, Faculty of Dentistry, Suez University, Suez, Egypt. | ||
| 2Oral Biology Department, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt. | ||
| 3Oral Medicine and Periodontology Department, Faculty of Dentistry, Suez University, Suez, Egypt. | ||
| Abstract | ||
| Introduction: Osteoporosis is a bone disorder with significant alterations in bone biologic material and consequent bone structural distraction. Low-level laser therapy (LLLT) has been studied as a physical modality that influences cellular activity through photochemical, photophysical, and photobiological mechanisms, making it an effective intervention for osteoporosis. Aim of the study: The current study was conducted to evaluate the impacts of low-level laser therapy on glucocorticoid induced osteoporosis at different time intervals. Methodology: This investigation involved 40 adult male albino rats, which were evenly distributed into four groups, each containing ten rats; control, DEX, 7 days LLLT, and 25 days LLLT. At the end of the experiment, all the rats were humanely euthanized. Their lower jaws were then collected and subjected to staining with Hematoxylin & Eosin (H&E) and immunohistochemical (IHC) analysis for RANKL and OPG. Results: DEX group revealed massive alveolar bone destruction with strong RANKL and weak OPG immunoreactivities. However, 7 days LLLT and 25 days LLLT groups showed improvements in the alveolar bone architecture with decreased RANKL and increased OPG immunoreactivities. Conclusion: Through RANKL/OPG ratio downregulation, LLLT improved bone architecture, encouraged bone healing, and stimulated osteogenesis over time. | ||
| Keywords | ||
| Glucocorticoid; Immunohistochemical; Low-Level Laser Therapy; Osteoporosis | ||
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