Effect of Implementing an Integrated Algorithm on Severity and Duration of Oropharyngeal Mucositis for Patients Receiving Allogenic Hematopoietic Stem Cell Transplantation | ||||
| Alexandria Scientific Nursing Journal | ||||
| Volume 27, Issue 1, March 2025, Page 210-232 PDF (355.78 K) | ||||
| Document Type: Research articles | ||||
| DOI: 10.21608/asalexu.2025.415005 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Soheir M Weheida,1; Naglaa Abd Allah Abd Elhafeez2; Almetwaly Mohamed , Sultan3; Asmaa Moustafa Said Ahmed4 | ||||
| 1Professor Medical Surgical Nursing, Faculty of Nursing, Alexandria University | ||||
| 2, Assistant professor Medical Surgical Nursing, Faculty of Nursing, Alexandria University | ||||
| 3Professor Consultant of Hematology& Bone Marrow Transplantation Nasser Institute Hospital, Cairo, Ministry of Health | ||||
| 4Assistant Lecturer Medical Surgical Nursing, Faculty of Nursing, Alexandria University | ||||
| Abstract | ||||
| Because of the conditioning regimen's toxicity, oropharyngeal mucositis (OPM) arises in the context of allogenic hematopoietic stem cell transplantation (HSCT). It culminates in inflammation, ulceration, as well as diminished oropharyngeal epithelium renewal rate. Patients' life quality is reduced by OPM, which is joined by severe pain, infection, bleeding and undernourishment. Few therapies are accessible right now. Creating algorithms and a multiagent system is projected to be more prosperous than employing a solitary intervention. Aim: Evaluate the effect of implementing an integrated algorithm on severity and duration of OPM for patients receiving allogenic HSCT. Settings: The present study was conducted at the Bone Marrow Transplant Unit, Nasser Institute Hospital for Treatment and Research, Cairo. Subjects: A convenience sample of 30 adult patients who were admitted for performing allogenic HSCT, followed the inclusion criteria and were assigned randomly into two equal groups (control group and study group), 15 patients in each group. Tools: five tools were used. Tool one: Bio sociodemographic data structured questionnaire. Tool two: Oral health management knowledge structured interview questionnaire. Tool three: Modified oral assessment guide (MOAG). Tool four: Swallowing exercises observational rating scale. Tool five: National Cancer Institute grading for oral mucositis severity and duration. Results: The study illustrated that there was a significant improvement in oral health management knowledge in the study group compared with the control group patients post transplantation (MCp <0.001*). Moreover, there was significant improvement in the total score of oral assessment in study group patients started from +6 day post transplantation compared with the control group (MCp<0.001*). Furthermore, there was significant improvement in the practice of the swallowing exercises post transplantation for the study group compared with control group (MCp<0.001*). Also, there was significant decline in severity and duration of OPM in study group compared with control group started from +6 day post transplantation (MCp <0.001). Conclusion: The integrated algorithm for patients receiving allogenic HSCT showed a positive effect on severity and duration of OPM as evidenced by improvement in oral health management knowledge, the overall total score of MOAG and practice of swallowing exercises. As well as significant decline in grade and duration of OPM. Recommendations: Replication of this study using large probability sample. | ||||
| Keywords | ||||
| Allogenic hematopoietic stem cell transplantation; Integrated algorithm; Oropharyngeal Mucositis | ||||
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