THE EFFECTIVENESS OF MORINGA (Moringa oleifera) ROOT EXTRACT GEL IN HEALING INCISION AND DIABETIC WOUND

Seran, Lucia Clarita Leki; Yuliani, Sri Hartati; Riswanto, Florentinus Dika Octa; Kamlasi, Jefri E.Y.; Dwiastuti, Rini

doi:10.21608/bfsa.2025.341050.2369

	THE EFFECTIVENESS OF MORINGA (Moringa oleifera) ROOT EXTRACT GEL IN HEALING INCISION AND DIABETIC WOUND
Bulletin of Pharmaceutical Sciences Assiut University
Volume 48, Issue 1, June 2025, Page 257-266 PDF (1.37 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2025.341050.2369
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Authors
Lucia Clarita Leki Seran ¹; Sri Hartati Yuliani ²; Florentinus Dika Octa Riswanto ³; Jefri E.Y. Kamlasi ⁴; Rini Dwiastuti ²
¹Master of Pharmacy, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, Indonesia
²Faculty of Pharmacy Paingan Maguwoharjo Depok Sleman Sanata Dharma University
³Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282, Indonesia
⁴Department of Pharmacy, Faculty of Health, Citra Bangsa University, Kupang 85111, Indonesia
Abstract
Skin is the outermost organ of the body that covers and protects the entire surface of the body. Incision wounds caused by a sharp object being cut and diabetic wounds caused by complications of diabetes. This study uses moringa (Moringa oleifera) root extract as the active substance because it acts as an antimicrobial that can accelerate wound closure and as an anti-inflammatory that can minimize the onset of inflammation. Moringa root extract is formulated into a gel because it is more effective in wound closure and easily relese form the dosage forms. This study aims to determine the effectiveness of moringa root extract gel in healing incision and diabetic wounds. Moringa root extract gel effectiveness test was conducted on 6 treatment groups, namely K1: positive control (bioplacenton® gel and star ag® gel), K2: normal control (no treatment), K3: negative control (base gel), K4: 5% gel treatment, K5: 10% gel treatment and K6: 15% gel treatment. Data analysis using SPSS software with One Way ANOVA test. The results of the effectiveness test showed that moringa root extract gel with a concentration variation of 5%, 10% and 15% had a healing effect on incision and diabetic wounds. The results of the One Way Anova test show that the data on the percentage of healing of incision and diabetic wounds are different with a significant value of p < 0.05 in each wound.
Keywords
diabetic wound; extract; gel; incision wound; moringa root


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