The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity
H. Rashed, E., M. Rabeh, N., G. El-Masry, H., M. Ahmed, A. (2025). The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity. EKB Journal Management System, 41(1), 31-48. doi: 10.21608/jhe.2025.415417
Eman H. Rashed; Naeem M. Rabeh; Hany G. El-Masry; Aml M. Ahmed. "The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity". EKB Journal Management System, 41, 1, 2025, 31-48. doi: 10.21608/jhe.2025.415417
H. Rashed, E., M. Rabeh, N., G. El-Masry, H., M. Ahmed, A. (2025). 'The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity', EKB Journal Management System, 41(1), pp. 31-48. doi: 10.21608/jhe.2025.415417
H. Rashed, E., M. Rabeh, N., G. El-Masry, H., M. Ahmed, A. The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity. EKB Journal Management System, 2025; 41(1): 31-48. doi: 10.21608/jhe.2025.415417

The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity

مجلة الاقتصاد المنزلي
Volume 41, Issue 1, March 2025, Page 31-48  XML PDF (442.26 K)
Document Type: المقالة الأصلية
DOI: 10.21608/jhe.2025.415417
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Authors
Eman H. Rashed1; Naeem M. Rabeh2; Hany G. El-Masry1; Aml M. Ahmed3
1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University
2Faculty of Nutrition Science, Helwan University
3Regional Center of Food and feed, Agriculture Research Center
Abstract
Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as a medicinal plant in both traditional and Western medicine. The aim of the present study was to investigate the effect of dried Ginkgo biloba leaves on oxidative stress as well as on liver functions of rats with induced liver toxicity. Thirty adult male albino rats (Sprague-Dawley strain), weighing about 180 ± 10 g,were divided randomly into two main groups as follows: the first group (negative control= 5 rats) was fed on basal diet. The second group (25 rats) was fed a basal diet then these rats were classified as the positive control group fed on basal diet only, however the other rats were fed on basal diet supplemented with dried ginkgo biloba at levels of  2.5%, 5% ,7.5% and 10% , respectively. After four weeks from the start of the experiment, the second groups from 2 to 5 were injected intraperitoneally with CCl₄  1mL/kg BW, a (1:1) mixture with corn oil for 3 days to induce liver toxicity. The existing study illustrated that Ginkgo biloba leaves at the four tested levels could significantly improve (P<0.05) the liver functions and lipid profile, increasing the activity of antioxidant enzymes and lowering the oxidative stress by eliminating the deleterious toxic effect of CCl₄, especially with the higher levels of Ginkgo biloba. The findings indicated that ginkgo leaves may have a protective effect role on the oxidative stress in rats with induced liver toxicity.
Keywords
Liver Toxicity; Ginkgo Biloba; Ccl4; oxidative stress; Rats; antioxidants
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