Validity of Platelet Mass Index in Platelet Transfusion in Management of Neonatal Thrombocytopenia

Gaber, Entesar Awn Allah; Meabed, Ashraf A.; abd el moneim, Hanan Mohammed; Gabari, Magda F; Elsayh, Khalid IA

doi:10.21608/aumj.2025.359696.1191

	Validity of Platelet Mass Index in Platelet Transfusion in Management of Neonatal Thrombocytopenia
Aswan University Medical Journal
Article 1, Volume 5, Issue 3, September 2025, Page 1-12 PDF (412.75 K)
Document Type: Original Article
DOI: 10.21608/aumj.2025.359696.1191
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Authors
Entesar Awn Allah Gaber ¹; Ashraf A. Meabed¹; Hanan Mohammed abd el moneim¹; Magda F Gabari¹; Khalid IA Elsayh²
¹Department of Pediatrics, Faculty of Medicine , Aswan university
²Department of Pediatrics, Faculty of Medicine , Assiut university
Abstract
ABSTRACT Background: Platelets serve as the primary defense mechanism against hemorrhage. Neonatal thrombocytopenia is a common hemostatic abnormality among newborns in the neonatal intensive care unit (NICU), using prophylactic platelet transfusion resulted in a higher rate of death or major bleeding. Objectives: This study aimed to compare the outcome of using Platelet Mass Index (PMI) versus Platelet Count (PC) guidelines in prophylactic platelet transfusion. Methodology: This single-blinded randomized controlled trial was carried out on 140 neonates with a platelet count <100,000/ml, admitted to the NICU. Results: A significantly higher percentage of patients needed platelets transfusion in the PC guideline group vs. the PMI guideline group (77.1% vs 17.1%). Further, there was a statistically significant higher percentage of hemorrhage, pulmonary hemorrhage and mortality in the PC group vs. the PMI group (24.3% vs 10%, p=0.025, 17.1% vs 5.7%, p=0.034v 22.9% vs 10%, p-value=0.040, respectively). Conclusion: This study demonstrated that transfusion strategies based on PMI guidelines resulted in higher post-transfusion platelet counts compared to the PC approach. Also, significant improvements in clinical outcomes were observed in the PMI group, including lower rates of bleeding, intracranial hemorrhage, and mortality. Keywords: NT, NICU, PMI Guideline, PC Guideline.
Keywords
NT; NICU; PMI Guideline; PC Guideline


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