Immunohistochemical Expression of NECTIN-4 in Urothelial Carcinoma of the Urinary Bladder | ||||
| Aswan University Medical Journal | ||||
| Article 3, Volume 5, Issue 3, September 2025, Page 26-35 PDF (542.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aumj.2025.352012.1182 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Shimaa Ghanem Abdelaziem  1; Shaimaa M.M. Bebars 1; Rasha Mohamed Samir Sayed1; Eman Muhammed Salah-Eldeen2
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| 1Department of Pathology, faculty of medicine Aswan university | ||||
| 2Department of Pathology, faculty of medicine Sohag university | ||||
| Abstract | ||||
| Introduction: Urothelial bladder carcinoma is the most common histopathological type of urinary bladder cancer. Immunohistochemistry (IHC), as a diagnostic or prognostic method, could be helpful particularly in the differentiation between muscle invasive and non-muscle invasive urothelial carcinoma (MIUC, NMIUC) as it has completely different implication on clinical management of the patients. Nectin-4 has served as a tumor associated inducer in a number of tumor types including urothelial carcinoma (UC). This study aimed to evaluate Nectin-4 expression in invasive and non-invasive urothelial carcinoma and its association with the available clinico-pathological parameters. Materials and Methods: This retrospective cohort observational study was conducted on 60 cases of UC to detect the IHC expression of Nectin-4. Results: Nectin-4 showed high expression in UC of the urinary bladder carcinoma (78.3%). A non-significant upward association was observed between Nectin-4 expression and muscle invasive UC cases. Nectin-4 was more expressed in larger tumor size, and high grade and stage UCs, but with no significant difference. Conclusions: These findings suggest an important function of Nectin-4 in predicting the prognosis in UC of the urinary bladder. Abbreviations: IHC; immunohistochemistry, MIUC; muscle invasive urothelial carcinoma, NMIUC; non-muscle invasive urothelial carcinoma, UC; urothelial carcinoma, | ||||
| Keywords | ||||
| Urothelial carcinoma; IHC; Nectin-4 | ||||
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