Cell-based in-vitro evaluation of Chia Seeds (Salvia hispanica L.) extract and Alpha-Linolenic Acid on human breast Cancer | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 10, October 2025, Page 467-477 PDF (687.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.356668.11235 | ||||
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| Authors | ||||
Nourhan Yehia1; Khaled Mahmoud  2; Nadia M. El-Beih1; Mai M. Zahra1
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| 1Zoology Department, Faculty of Science, Ain Shams University | ||||
| 2Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt | ||||
| Abstract | ||||
| Breast cancer (BC) is the most common malignancy and the main cause of cancer death among women globally, with a considerable increase in BC cases. Today, alternative treatment approaches have become necessary to improve the rate of BC patients. Therefore, the present study investigates the anticancer effect of Chia (Salvia hispanica L.) seed extract (CSE), and one of the most bioactive components is alpha linolenic acid (ALA), on the MCF-7 cell line. The results showed that CSE and ALA were specifically able to inhibit proliferation with IC50 CSE=74.1µg/ml and ALA=133.3µg/ml. CSE and ALA induced morphological changes related to apoptosis, inhibition of cell adhesion, migration and reduced spheroids volumes of MCF-7 cells depending on concentration. CSE was more active on cytochrome C in cytosol, increased caspase3, and decreased protein expression of BCL2 in MCF-7 cells. | ||||
| Keywords | ||||
| Salvia hispanica; MCF7; Apoptosis -ALA- apoptotic related genes | ||||
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