Assessment of measles vaccine effectiveness and its correlation with IL-6 and INF-γ in vaccinated children of Thi-Qar Province, Iraq | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 12 March 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.359152.2527 | ||||
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| Authors | ||||
Abdulrahman Seger Gumar  ; Talib Hassan Ali
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| Department of Microbiology, College of Medicine, University of Thi-Qar, 64001, Iraq. | ||||
| Abstract | ||||
| Background: Measles is still an endemic disease in Iraq, although it is preventable via vaccination. This study aimed to evaluate the effectiveness of measles vaccine which used in Thi-Qar province, Iraq. Methods: The case-control study included 176 children (117 vaccinated and 59 unvaccinated). The ELISA technique was used to detect measles virus IgG in children less than 13 years old. The person's informed consent was obtained. Results: The seroprevalence of measles virus IgG was positive in 91 (77.8%) of 117 vaccinated children, whereas 24 (40.7%) of 59 unvaccinated children tested positive showing a significant difference between both groups (p value < 0.001). In the vaccinated group, a significant difference was observed between males and females (p value = 0.028). In contrast, no significant difference was found in the unvaccinated group based on the chi-square test. In addition, this study showed significant differences between the case and control groups (p value = 0.002) and male and female in the case group (p value = 0.016), by using t-test. The results found a weak negative correlation with IL-6 (r = -0.191, p value = 0.039), but no correlation with INF-γ (r = -0.095, p value = 0.311) by using Pearson correlation. All at a p value > 0.05. Conclusions: Findings of this study revealed that portion of children (22.2%) did not develop immunity against the measles virus. So, there must be increased efforts to achieve maximum immunization coverage, educate population about importance of vaccination, and perform more studies to ensure measles vaccine efficacy. | ||||
| Keywords | ||||
| Measles vaccine; MMR vaccine; IL-6; INF-γ | ||||
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