Relationship between Severity of Neonatal Thrombocytopenia and Prophylactic Platelet Transfusion in NICU

Gaber, Entesar Awn Allah; Meabed, Ashraf A.; Gabari, Magda Farghalli; Elsayh, Khalid IA; abd el moneim, Hanan Mohammed

doi:10.21608/aumj.2025.362991.1197

	Relationship between Severity of Neonatal Thrombocytopenia and Prophylactic Platelet Transfusion in NICU
Aswan University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 12 March 2025
Document Type: Original Article
DOI: 10.21608/aumj.2025.362991.1197
View on SCiNiTO
Authors
Entesar Awn Allah Gaber ¹; Ashraf A. Meabed¹; Magda Farghalli Gabari¹; Khalid IA Elsayh²; Hanan Mohammed abd el moneim¹
¹Department of Pediatrics , Faculty of Medicine, Aswan University
²Department of Pediatrics , Faculty of Medicine, Assiut University
Abstract
Background: Prophylactic platelet transfusion carries higher risk of complications, however, there no solid proof that a newborn's platelet count and severe bleeding are related. Objectives: The current study aimed to explore the association between NT severity and platelet transfusion and the possible complications based on NT severity. Methodology: 140 newborns hospitalized to the Neonatal Intensive Care Unit with a platelet count <100,000/ml participated in this randomized controlled experiment. Results: cases with severe NT had higher rates of sepsis and NEC (53% and 26%) than those with moderate NT (34% and 9.5%). Also, need for platelet transfusion was higher among severe (70%) vs moderate NT (27%) cases (p<0.001).In addition, NEC was higher in cases needed transfusions and proportion of patients with hemorrhage was higher in those needed transfusion or with hemorrhage. Likewise, the need for transfusion and cases with hemorrhage was associated with higher prevalence of mortality (33.3% and 83%) than no need (1.4% and 2.6%) (p<0.001). Conclusion: the current study shredded the light on the positive relationship between NT severity, need for transfusion and hemorrhage with the patients’ main outcomes i.e., hemorrhage and mortality. Keywords: NT, NICU, Hemorrhage, NEC, Sepsis.
Keywords
NT; NICU; Hemorrhage; NEC; Sepsis


Statistics Article View: 75