Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.
Bahriz, A., Mansour, M., Ibrahim, A., Khalil, D., El-Noury, H. (2020). Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.. EKB Journal Management System, 37(1), -. doi: 10.21608/bmfj.2020.22710.1206
Ahmed Fathy Bahriz; Mohamed El-Metwally Mansour; Amany Nasr Ibrahim; Doaa Mohamady Khalil; Heba Abd El-Hafeez El-Noury. "Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.". EKB Journal Management System, 37, 1, 2020, -. doi: 10.21608/bmfj.2020.22710.1206
Bahriz, A., Mansour, M., Ibrahim, A., Khalil, D., El-Noury, H. (2020). 'Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.', EKB Journal Management System, 37(1), pp. -. doi: 10.21608/bmfj.2020.22710.1206
Bahriz, A., Mansour, M., Ibrahim, A., Khalil, D., El-Noury, H. Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.. EKB Journal Management System, 2020; 37(1): -. doi: 10.21608/bmfj.2020.22710.1206

Effect of Exenatide, Metformin and Folic Acid on Experimentally Induced Metabolic–Cognitive Syndrome in Rats.

Benha Medical Journal
Volume 37, Issue 1, May 2020    PDF (1.1 M)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.22710.1206
Authors
Ahmed Fathy Bahriz1; Mohamed El-Metwally Mansour2; Amany Nasr Ibrahim3; Doaa Mohamady Khalil* 4; Heba Abd El-Hafeez El-Noury5
1professor of clinical pharmacology, faculty of medicine, banha univerisity
2professor of clinical pharmacology, faculty of medicine,benha univerisity
3Assistant Professor of Clinical Pharmacology, Faculty of Medicine Benha University
4Assistant lecturer, clinical pharmacology department, faculty of medicine, banha univerisity
5Lecturer of clincal pharmacology,faculty of medicine ,benha university
Abstract
ABSTRACT

Background: Metabolic syndrome (MetS) and its relationship with cognitive impairment has been the subject of extensive research.

Purpose: This study was designed to determine the effect of MetS on cognitive function, and the possibility of modulating this effect by exenatide, metformin and folic acid.

Materials and Methods: 30 adult male albino rats were divided in 5 groups. Group (I): received a standard rat chow, Group (II): MetS none treated rats fed with 60% fructose added to the standard rat chow, Group (III): MetS treated with exenatide, Group (IV): MetS treated with metformin, Group (V): MetS treated with folic acid. At the end of the experiment, fasting blood glucose, fasting plasma insulin, HOMA-IR index, serum triglyceride, HDL-C, dopamine and BDNF levels in brain tissue were measured and cognitive performance was assessed by Morris water maze (MWM) test.

Results: MetS rats increased fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, serum triglycerides and decreased HDL-C, dopamine and BDNF and showed memory impairment in MWM test. All treated groups resulted in decrease in fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, and serum triglycerides and increase in HDL-C, dopamine and BDNF. Also showed memory improvement in MWM test.

Conclusion: MetS was associated with cognitive impairment. Exenatide, metformin and folic acid improved cognitive function in addition to improvement of metabolic parameters.
Keywords
cognition; exenatide; folic acid; metabolic syndrome; metformin
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