The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer
Elgenedi, H., Abdelhalim, I., Eita, M., Al Shahat, M., Arafa, M. (2020). The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer. EKB Journal Management System, 37(1), -. doi: 10.21608/bmfj.2020.23459.1212
Hind Elgenedi; Inas Abdelhalim; Mahfouz Abdel-Aziz Eita; Maiy Al Shahat; Mohamed Arafa. "The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer". EKB Journal Management System, 37, 1, 2020, -. doi: 10.21608/bmfj.2020.23459.1212
Elgenedi, H., Abdelhalim, I., Eita, M., Al Shahat, M., Arafa, M. (2020). 'The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer', EKB Journal Management System, 37(1), pp. -. doi: 10.21608/bmfj.2020.23459.1212
Elgenedi, H., Abdelhalim, I., Eita, M., Al Shahat, M., Arafa, M. The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer. EKB Journal Management System, 2020; 37(1): -. doi: 10.21608/bmfj.2020.23459.1212

The Predictive and prognostic relevance of P53 oncogene in patients with serous epithelial ovarian cancer

Benha Medical Journal
Volume 37, Issue 1, May 2020  XML PDF (826.13 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.23459.1212
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Authors
Hind Elgenedi email 1; Inas Abdelhalim2; Mahfouz Abdel-Aziz Eita3; Maiy Al Shahat4; Mohamed Arafa5
1Clinical Oncology Department,Faculty of Medicine, Mansoura university, Dakahleyia, Egypt
2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Mansoura University, Egypt
3Clinical Oncology Department, Faculty of Medicine, Mansoura University
4Clinical Oncology Department, Faculty of Medicine Mansoura University
5Clinical Pathology Department, Faculty of Medicine , Mansoura University
Abstract
Background: Ovarian cancer is a common malignant gynecological tumor that is difficult to diagnose early, progresses rapidly, and causes high mortality.

Aims of our study: to assess the relationship of P53 with other clinico-pathological parameters and the effect of P53 on patients’ out come.

Subjects and methods: This study was conducted at Clinical Oncology and Nuclear Medicine Department with Pathology Department, Faculty of Medicine, Mansoura University. The study was carried out on 50 patients with serous epithelial ovarian cancer presented to receive adjuvant treatments following a primary surgery and were followed from the first day after surgery, follow-up started on January, 2012 till February, 2016. P53 expression was assessed immunohistochemically on formalin-fixed paraffin-embedded tissues, and Secondary red Envision system. patients were given adjuvant treatment(s) according to according to NCCN guidelines. The primary endpoint of the study was loco regional recurrence, and distant metastasis. At the end of the follow-up period, the patient clinico-pathological data and patient outcome were collected.

Results: we found that P53 negative tumors have a better OS & DFS at 3 year than with P53 positive tumors, but not reached statistically significant differences ( P value = 0.04 & 0.05 respectively).

Conclusion: Our results showed no statically significant difference between P53 expression OS & DFS,needs to be evaluated in other study including large number of patients before using it as a marker for the outcome in these tumors.
Keywords
P53; ovarian cancer; Disease-free survival; Prognostic markers
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