Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients
El-sayed, H., Marei, A., Elaidy, A., Khalil, A., El Maghraby, H. (2025). Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients. EKB Journal Management System, 34(3), -. doi: 10.21608/ejmm.2025.365723.1509
Hend A. El-sayed; Ayman M. Marei; Aya M. Elaidy; Ahmed M. Khalil; Hanaa M. El Maghraby. "Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients". EKB Journal Management System, 34, 3, 2025, -. doi: 10.21608/ejmm.2025.365723.1509
El-sayed, H., Marei, A., Elaidy, A., Khalil, A., El Maghraby, H. (2025). 'Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients', EKB Journal Management System, 34(3), pp. -. doi: 10.21608/ejmm.2025.365723.1509
El-sayed, H., Marei, A., Elaidy, A., Khalil, A., El Maghraby, H. Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients. EKB Journal Management System, 2025; 34(3): -. doi: 10.21608/ejmm.2025.365723.1509

Serum Level and Genetic Polymorphism of Angiotensin Converting Enzyme in Neonatal Sepsis Patients

Egyptian Journal of Medical Microbiology
Volume 34, Issue 3, July 2025  XML
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2025.365723.1509
View on SCiNiTO View on SCiNiTO
Authors
Hend A. El-sayed1; Ayman M. Marei1; Aya M. Elaidy email 1; Ahmed M. Khalil2; Hanaa M. El Maghraby1
1Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
2Pediatric and Neonatology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
Abstract
Background: Neonatal sepsis (NS) is an important worldwide health problem predominantly in developing regions, Susceptibility to sepsis varies according to various neonatal factors such as innate immune response and pathogens exist in the local environment. Objective: determination of serum level and genetic Polymorphism of angiotensin converting enzyme (ACE (in NS. Methodology: this case-control study included 116 subjects, 58 in each group. The diagnosis of NS has been based on: thorough history taking, clinical signs and symptoms of NS and laboratory investigations. Blood samples were collected for inoculation on blood culture bottles followed by isolation and identification of the causative bacteria. Detection of polymorphism in ACE gene using Polymerase chain reaction (PCR) and Measurement of serum level of ACE by Enzyme linked immunsorbent assay (ELISA) were done. Results: Klebseilla was found to be the most common encountered organism.There is a significant increase in serum ACE level in NS cases as compared to healthy controls (p=0.0002). DD genotype was dominant in NS patients, while II genotype was dominant in healthy controls (p=0.00001(. The highest level of ACE was detected in DD genotypes in comparison to other genotypes with a statistically significant differences (p= 0.00005). Conclusion: ACE may play a role as a biomarker for neonatal sepsis pathogenesis.
Keywords
ACE; polymorphism; neonatal sepsis
Statistics
Article View: 51