Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor
Saad, A., Omara, M., Hegazy, A., Fathey, A. (2025). Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor. EKB Journal Management System, 29(2), 54-62. doi: 10.21608/egyfs.2025.417772
Abd El-Haseib Salah Saad; Mohamed Abdelghani Omara; Asmahan Effat Ali Hegazy; Amira Ahmed Fathey. "Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor". EKB Journal Management System, 29, 2, 2025, 54-62. doi: 10.21608/egyfs.2025.417772
Saad, A., Omara, M., Hegazy, A., Fathey, A. (2025). 'Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor', EKB Journal Management System, 29(2), pp. 54-62. doi: 10.21608/egyfs.2025.417772
Saad, A., Omara, M., Hegazy, A., Fathey, A. Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor. EKB Journal Management System, 2025; 29(2): 54-62. doi: 10.21608/egyfs.2025.417772

Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 2 - Serial Number 11106352, March 2025, Page 54-62  XML PDF (269.82 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.417772
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Authors
Abd El-Haseib Salah Saad1; Mohamed Abdelghani Omara2; Asmahan Effat Ali Hegazy* 3; Amira Ahmed Fathey4
1Assistant Professor of Obstetrics & Gynecology, Faculty of Medicine – Menofia University
2Professor of Obstetrics & Gynecology, Faculty of Medicine– Menofia University
3M.B.B.CH, Menoufia University; Resident of obstetrics and gynecology, Menouf General Hospital,
4Lecturer of Obstetrics & Gynecology, Faculty of Medicine – Menofia University
Abstract
Background: Copeptin is a stable by-product of the syn-thesis of arginine-vasopressin (AVP); it can be accurately and quantitatively measured in plasma and mimics the re-lease of AVP.    
Aim of work: to assess the importance of maternal serum copeptin levels in diagnosis of threatened preterm labor and prediction of preterm birth.  
Subjects & methods: This study was carried out as a pro-spective case control on 88 pregnant women at Obstet-rics and Gynecology Department, Faculty of Medicine, Menoufia University. They were divided into two groups: Group I (Case group n=58): including 58 pregnant la-dies who admitted for threatened preterm labor.  Group II (Control group n=30): including 30 healthy pregnant ladies of matched age, parity, and gestational age.   
Results: Serum copeptin was significantly higher in cas-es with preterm labor than term controls (641.29±167.87 pg/ml vs 192.67±71.16 pg/ml) respectively. Regard-ing the outcome serum copeptin was significantly high-er in cases with preterm birth than cases with term birth (751.57±169.923 pg/ml vs 642±163pg/dl) respectively. The serum copeptin cutoff value is ≥ 380 pg/ml, the area under the curve is equal to 1.00, according to our ROC data. The sensitivity, specificity, positive predictive and negative predictive values of serum copeptin were 98.3%, 100%, 100% and 96.8% respectively.  
Conclusion: Maternal serum copeptin levels can serve as a valuable diagnostic and predictive marker in cases of threatened preterm labor and preterm birth.
Keywords
Serum Copeptin; Diagnostic and Prognostic Marker; Threatened Preterm Labor. 
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