A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range
Said, B., Shoukry, E., Mohamed, E., Hendawy, H., Khaled, E. (2025). A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range. EKB Journal Management System, 68(11), 643-651. doi: 10.21608/ejchem.2025.361974.11328
Basmat Amal Said; Eman Mohamed Shoukry; Eman Fares Mohamed; hassan Hendawy; Elmorsy A Khaled. "A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range". EKB Journal Management System, 68, 11, 2025, 643-651. doi: 10.21608/ejchem.2025.361974.11328
Said, B., Shoukry, E., Mohamed, E., Hendawy, H., Khaled, E. (2025). 'A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range', EKB Journal Management System, 68(11), pp. 643-651. doi: 10.21608/ejchem.2025.361974.11328
Said, B., Shoukry, E., Mohamed, E., Hendawy, H., Khaled, E. A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range. EKB Journal Management System, 2025; 68(11): 643-651. doi: 10.21608/ejchem.2025.361974.11328

A Novel Potentiometric Sensor for Eletriptan hydrobromide based on 2, 6-di-O-methyl-β-Cyclodextrin-carbon nanotube platform: High Sensitivity and Wide Dynamic Range

Egyptian Journal of Chemistry
Volume 68, Issue 11, November 2025, Page 643-651  XML PDF (379.4 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.361974.11328
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Authors
Basmat Amal Said1; Eman Mohamed Shoukry1; Eman Fares Mohamed1; hassan Hendawyorcid 2; Elmorsy A Khaled email orcid 3
1Faculty of Science (Girls), Al-Azhar University, Naser City, Egypt
2Egyptian Drug Authority, Giza, Egypt
3Applied Organic Chemistry Department, National Research Centre, El Bohouth St., Dokki, 12622 Giza, Egypt
Abstract
The present study introduces a novel screen-printed planner potentiometric sensor for sensitive determination of eletriptan hydrobromide (ELE). Comprehensive and deep optimization trials were carried out concerning the nature and content of the sensing element, anionic sites, plasticizer, carbonaceous nanomaterial, performance under different pH values, and other electroanalytical parameters. Among the different fabricated sensors, the printed sensor integrated with the 2,6-di-o-methyl β-cyclodextrin-multiwall carbon nanotubes nanocomposites (β-CD/MWCNTs) exhibit ideal Nernstian slope value (59.7±0.6 mV decade-1) within a linear dynamic ELE concentration range from 10-8 to 10-3 mol L-1 and limit of detection 1.0×10-8 molL-1. Moreover, the presented disposable sensors show high potential stability with a prolonged operational lifetime, and a fast response time of 4s, representing an efficient analytical tool for fast and sensitive assay of ELE contents in authentic and marketed pharmaceutical tablets with acceptable average recoveries (100.11±1.3%).
Keywords
: Eletriptan hydrobromide; 2,6-di-o-methyl β-cyclodextrin; Carbonaceous nanostructures; Potentiometric sensor; Pharmaceutical samples
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