"Histological and Immunohistochemical Study of the Protective Effect of Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors on Streptozotocin Induced Pancreatic Damage In Adult Male Albino Rats" | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 17 March 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2025.358993.1898 | ||||
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| Authors | ||||
youssra Magdy Hassan  1; Abdel Hamid Sayed AboBakr2; Medhat Ata3; Mohamed Ahmed Desouky4
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| 1Anatomy and Embryology department Faculty of medicine Minia university | ||||
| 2Assistant professor of Anatomy and Embryology, Faculty of Medicine, Minia University, Egypt | ||||
| 3Assistant professor of Anatomy and Embryology Faculty of Medicine, Minia University | ||||
| 4Anatomy and Embryology department Faculty of medicine Minia university | ||||
| Abstract | ||||
| Background: SGLT2 inhibitor is a type of medication prescribed for treatment of type 2 diabetes. By prevention the reabsorption of glucose in the kidneys, these drugs facilitate glucose removal through urine. Aim: Investigate protective effect SGLT2 inhibitors on pancreatic damage induced by streptozotocin. Materials and Methods: Study involved forty adult male albino rats; they were divided into four groups. Group I: consisted of 10 rats administered three ml distilled water orally once daily. Group II: This group included 10 rats administered Jardiance (Empagliflozin, an SGLT2 inhibitor) at a dose of 10 mg/kg/day, dissolved in drinking water for 28 days. Group III: This group included 10 rats fasted for 12 hours before receiving a single dose of streptozotocin (50 mg/kg) intraperitoneally to induce pancreatic damage. Group IV: This group included 10 rats that received Jardiance (Empagliflozin, an SGLT2 inhibitor) at a dose of 10 mg/kg/day, dissolved in drinking water for 14 days before STZ injection. Then, rats were injected with a single dose of streptozotocin (50 mg/kg) intraperitoneally and continued to receive the daily dose of Jardiance for 14 days. At end of the experiment (28 days), pancreatic tissue samples were collected for H&E staining and immunohistochemical analysis. Results: Degenerative changes were observed in the pancreas of Group III. Protection with SGLT2 inhibitors attenuated degenerative effects, demonstrating a protective effect on pancreatic tissue. Conclusion: SGLT2 inhibitors effectively attenuate the degenerative effects induced by streptozotocin in the pancreas. These results suggest that SGLT2 inhibitors offer a therapeutic strategy for protecting pancreatic tissue. | ||||
| Keywords | ||||
| Sodium glucose co-transporter 2 inhibitors; streptozotocin; Pancreas | ||||
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