Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer | ||
| Archives of Pharmaceutical Sciences Ain Shams University | ||
| Article 4, Volume 9, Issue 1, June 2025, Pages 52-62 PDF (592.97 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aps.2024.321065.1196 | ||
| Authors | ||
| Rana A. Amer1; Amany M. Kamal* 2; Reham A. A. El-shemy3; Hala O. El-Mesallamy2, 4 | ||
| 1Cairo Dermatology Hospital, Egypt | ||
| 2Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt | ||
| 3Department of Clinical and Chemical Pathology, National Cancer Institute NCI, Cairo University, Cairo, Egypt | ||
| 4Department of Biochemistry, Faculty of Pharmacy, Galala University, Suez, Egypt | ||
| Abstract | ||
| Necroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes. Numerous inputs can initiate the process, which is regulated by pseudokinase mixed lineage kinase domain-like protein (MLKL) and the activation of receptor-interacting serine/threonine protein kinases 1 and 3 (RIPK1, RIPK3). The well-studied executor RIPK1 affects important cellular processes and acts as a critical crossroad for several biochemical pathways through its interactions with numerous proteins. Currently, it is thought that necroptosis acts as a backup plan if apoptosis fails. Necroptosis possesses antiviral, antibacterial, and anticancer effects by getting rid of germ-filled or proliferating cells and promoting the development of a strong immune system. However, its potent anti-inflammatory and cytotoxic effects on cells can also lead to severe tissue injury, chronic sickness, and even tumor development. Not much is known about its role in the formation of tumors. In this review, we highlight recent discoveries about the biological significance of necroptosis, its conflicting functions in cancer, and its capacity to control cell destiny. As a pharmacologically controlled process, targeting necroptosis might be a valuable therapeutic intervention technique in cancer treatment. | ||
| Keywords | ||
| Cancer; Necroptosis; MLKL; RIPK1; RIPK3 | ||
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