Fecal Calprotectin as Screening Parameter for Hepatic Encephalopathy

Abd El Mawla Amin, Ahmed Mohammad; Gad, Magdy Abdel Mawgoud; Shams Eldin Negm, Ahmed Ahmed

doi:10.21608/bmfj.2025.342889.2276

	Fecal Calprotectin as Screening Parameter for Hepatic Encephalopathy
Benha Medical Journal
Volume 42, Issue 7, July 2025, Page 816-825 PDF (853.33 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.342889.2276
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Authors
Ahmed Mohammad Abd El Mawla Amin¹; Magdy Abdel Mawgoud Gad¹; Ahmed Ahmed Shams Eldin Negm ²
¹Department of Hepatology, Gastroenterology and Infectious diseases, Faculty of medicine - Benha University
²M.B.B.CH department of Hepatology, Gastroenterology and Infectious diseases, Faculty of medicine - Benha University
Abstract
Background: Hepatic encephalopathy is a big neuropsychiatric problem that can happen with cirrhosis. It slowly happens in people with cirrhosis, starting with changes in their sleep patterns and moving on to asterixis, stupor, and coma. Aim: To evaluate the role of fecal calprotectin is a good screening parameter of hepatic encephalopathy in patients with cirrhosis of the liver. Patients and methods: This comparative cross-sectional research has been conducted on 80 subjects divided into both groups Group I (N=60): Cases with cirrhosis suffering hepatic encephalopathy and Group II (N=20): Healthy subjects as controls matched with study group in sex and age who were admitted at Department of Hepatology, Gastroenterology and Infectious Diseases, Damanhur Teaching Hospital. Results: With AUC of 0.929, Fecal Calprotectin can significantly predict the incidence of hepatic encephalopathy (P44.6 μg/mg, with range 16.7-640, with 78.57% sensitivity, 92.11% specificity 91.7% PPV and 79.5% NPV. With AUC of 0.966, Serum ammonia can significantly predict the incidence of hepatic encephalopathy (P72.5 mcg/dL, with 90.00% sensitivity, 100.00% specificity, 100.0% PPV and 76.9% NPV. There was an insignificant relation between grades of encephalopathy and fecal calprotectin level, as fecal calprotectin level was insignificant different among the grades of encephalopathy. Conclusion: Fecal calprotectin, especially at higher cutoff values, shows potential as a predictive biomarker for hepatic encephalopathy, providing a non-invasive method for early detection and risk evaluation in individuals with cirrhosis.
Keywords
Fecal calprotectin; hepatic encephalopathy; cirrhosis


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