Cardiac Affection in Children with Chronic Renal Failure: Case-Control Study | ||||
| Fayoum University Medical Journal | ||||
| Volume 14, Issue 3, March 2025, Page 69-81 PDF (512.1 K) | ||||
| Document Type: Full Length research Papers | ||||
| DOI: 10.21608/fumj.2025.312819.1380 | ||||
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| Authors | ||||
Sara Ibrahim Abo Elnour1; Ashraf Sayed Kamel1; Mona Gamal Mostafa2; Ahmed Ibrahim Mohamed  3
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| 1Pediatric department, Faculty of medicine, Fayoum university, Fayoum, Egypt | ||||
| 2Clinical pathology department, Faculty of medicine, Fayoum university, Fayoum, Egypt | ||||
| 3Pediatrics department, Faculty of medicine, Fayoum university, Fayoum, Egypt | ||||
| Abstract | ||||
| Background: Chronic renal failure is a devastating disease facing children, with several life-threatening complications, where cardiovascular diseases are on top of them. Aim of the work: To evaluate cardiac affection in children with chronic renal failure through echocardiography, ECG & high sensitivity troponin I level. Methods: A case-control study which included 40 children/adolescents aged 2-14 years with CRF and 20 apparently healthy subjects from age matched population as a control. Results: Regarding echo parameters, LVEDD & LVESD were significantly increased in cases compared to controls (P-value < 0.001) and in hemodialysis cases compared to conservative cases (P-value = 0.011 & 0.03 respectively). EF and FS were significantly decreased in cases compared to controls (P-value = 0.029 & 0.036 respectively), and among hemodialysis cases compared to conservative cases (P-value <0.001). Impaired diastolic function was found in 20 cases (50%), and impaired systolic function was found in 9 cases (22.5%). Regarding ECG findings, QRS duration, QRS amplitude & QTc values were significantly higher in cases compared to controls (P-value = 0.008, <0.001 & 0.036 respectively), and among hemodialysis cases compared to conservative cases (P-value <0.001, <0.001 & 0.04 respectively). Regarding hs-cTnI level, 8 cases were positive, no positive subjects in controls, and there was no significant difference between cases and controls (P-value = 0.08) or between hemodialysis cases and conservative cases (P-value = 0.171). Conclusion: CRF in pediatrics is associated with a highly prevailing LVH, systolic/diastolic dysfunction, prolonged QTc with no significant elevation of troponin I level. | ||||
| Keywords | ||||
| CRF; CVD; LVH; QTc; hs-cTnI | ||||
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