Interrelation of Urinary Tract Infections and Renal Failure: Evaluating Pathogen Prevalence and the Diagnostic Utility of FGF23 and CFH Biomarkers | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 34, Issue 2, April 2025, Pages 301-407 PDF (5.15 M) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.368537.1523 | ||
| Authors | ||
| Ahmed H.K. Alkarewy* ; Ali J.A Alyassery; Masar R.R. Al-Mousawi | ||
| Department of Medical Microbiology, College of Medicine, University of Kerbala, Kerbala, Iraq | ||
| Abstract | ||
| Background: Urinary tract infections (UTIs) are prevalent bacterial infections, particularly among females, often leading to significant morbidity. Renal failure (RF) compromises immune defenses, and increasing susceptibility to infections. Biomarkers such as Fibroblast Growth Factor 23 (FGF23) and Complement Factor H (CFH) have been implicated in renal pathophysiology. Objective: The aim of this work is to investigate the interplay between UTIs and RF by analyzing pathogen prevalence and assessing FGF23 and CFH levels in affected patients. Methodology: A cross-sectional study was conducted involving patients diagnosed with UTI and/or RF. Midstream urine samples were collected for microbiological analysis using the VITEK® 2 Compact system. Serum levels of FGF23 and CFH were measured using enzyme-linked immunosorbent assay, respectively. Data were analyzed to identify associations between pathogen prevalence, biomarker levels, and patient demographics. Results. The study revealed a higher incidence of UTIs among younger females. Escherichia coli was identified as the predominant uropathogen. Patients with RF exhibited significantly elevated levels of FGF23 and CFH compared to those without RF. These biomarkers demonstrated high predictive accuracy for renal impairment. Conclusion: The findings highlight the importance of monitoring FGF23 and CFH levels in patients with renal impairment. Early detection of elevated levels can facilitate timely interventions to mitigate progression and manage complications. Understanding demographic predispositions to UTIs can inform targeted prevention strategies, particularly among younger females, to reduce infection rates and associated renal complications. | ||
| Keywords | ||
| Urinary tract infection; Renal failure; FGF23; CFH; Biomarkers | ||
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