Maresin-1 mitigates streptozotocin induced diabetic nephropathy in rats via up-regulation of Nrf2/HO-1 pathway | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Volume 45, Issue 2, April 2025, Pages 246-257 PDF (781.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2025.347094.1193 | ||
| Authors | ||
| Suzan A Khodir* 1; Dina Elzeiny2; Noha Abd El-aziz3; Ahmed Abdel-monem Elmetwally4; Sara Mohamed Mowafy5; Sarah Abo EL-Soud6; Ahmed Kamal7; Shorouk Elmorshdy8; Rania Mansour9 | ||
| 1Medical physiology department, faculty of Medicine, Menoufia University | ||
| 2Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Mansoura University, Egypt. Medical Biochemistry and Molecular Biology Department, Faculty of medicine, New Mansoura University, Egypt. | ||
| 3Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 4Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt. 35516 | ||
| 5Anatomy and Embryology Department, Faculty of Medicine, Portsaid University, Portsaid, Egypt | ||
| 6Pathology Department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt. | ||
| 7Internal Medicine and Nephrology department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt. | ||
| 8Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 9Medical Physiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Introduction: One serious health issue is diabetic nephropathy (DN). A lipid mediator that is naturally produced from omega-3 fatty acids, maresin-1 (MaR1), may be able to considerably lessen the symptoms of a number of inflammatory illnesses. Objective: to assess the potential underlying processes and the protective impact of Maresin-1 in DN caused by STZ Materials and Methods: Thirty adult male albino rats were divided into: control, DN group, and DN+MaR1 group (10/group). levels of urine albumin, renal SOD, creatinine clearance, renal MDA, renal TNF-α, renal IL-6, and renal genes expression of nuclear factor E2-related factor 2 (Nrf2) and heme-oxygenase 1 (HO-1) in addition to serum levels of glucose, glycosylated Hb A1c, urea, and creatinine. Furthermore, renal histopathology and immunohistochemical analyses were performed. Results Along with urinary albumin, renal MDA, renal TNF-α, and renal IL-6, DN significantly increased serum levels of glucose, glycosylated Hb A1c, urea, and creatinine when compared to the control. Additionally, it dramatically reduced the expression of the renal genes Nrf2 and HO-1, renal SOD, and creatinine clearance levels. In addition, the DN group's NF-kB immunoreaction and Caspase-3 were both upregulated in comparison to the control. The DN+MaR1 group showed a considerable improvement in STZ-induced DN changes. Conclusion: Through anti-oxidant and anti-inflammatory mechanisms, apoptosis suppression, and the up-regulation of Nrf2 and HO-1 renal gene expressions, MaR1 provides significant protective benefits against STZ-induced DN. | ||
| Keywords | ||
| Diabetic Nephropathy; HO-1; Maresin-1; Nf-kB; Nrf2 | ||
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