The Role of Biomarkers in Monitoring Liver Disease Progression: Insights into AFP, and P53 | ||||
| المجلة العربية للعلوم الزراعية | ||||
| Volume 8, Issue 26, April 2025, Page 89-104 PDF (719.78 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/asajs.2025.419031 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Naglaa M Hamdy1; Essam Z. El Sayed2; Sahar A. Allam3 | ||||
| 1 Natural Products Unit, Medicinal and Aromatic Department, Desert Research Center, Cairo, Egypt | ||||
| 2Agro-Industrialization Unit, Department of Plant Production, Desert Research Center, Cairo, Egypt | ||||
| 3Infectious Disease Unit, Animal and Poultry Health Department, Animal and Poultry Production Division, Desert Research Center, Cairo, Egypt | ||||
| Abstract | ||||
| Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern, often progressing to hepatocellular carcinoma (HCC), a leading cause of liver cancer. This research investigates the relationship between NAFLD and HCC in HepG2 cells and the roles of p53 and alpha-fetoprotein (AFP) in these processes. The study investigated that the inactivation of p53 (NAFLD = 22.5 ±2.02U/ml, HCC = 55 ±2.21U/ml) contributes to the progression of NAFLD to HCC, and that elevated AFP levels (NAFLD = 13 ±1.17ng/ml, HCC = ±1.2ng/ml) serve as both a biomarker and a contributor to liver carcinogenesis (p-value < 0.5). The findings highlight that the elevated values of AFP, but not of P53, may help in understanding the transformation in the context of NAFLD and liver cancer. | ||||
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