Clinicopathologic Significance of Fascin Expression in Different Grades of Gliomas | ||
| SVU-International Journal of Medical Sciences | ||
| Article 57, Volume 8, Issue 1, January 2025, Pages 660-666 PDF (331.44 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2025.363673.2125 | ||
| Authors | ||
| Rasha Mokhtar Abdelkareem* 1; Amira A. Abdelnaby1; Karam Kenawy2; Hala S. E Alaa Edin3 | ||
| 1Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 2Department of Neurosurgery, Sohag University hospital, Sohag University, Sohag , Egypt. | ||
| 3Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| Abstract | ||
| Background: Gliomas account for more than two-thirds of all malignant brain tumors. Fascin is a cytoskeleton cell protein that plays a crucial role in invasion and spread of the tumor. However the exact role is not clear. Objectives: The purpose of this study is to 1) assess Fascin expression in different types and grades of gliomas and 2) find out the relationship between its expression and the clincopathological factors. Patients and methods: Immunohistochemical (IHC) staining with Fascin was studied on 70 cases of gliomas using a mouse monoclonal antibody against human fascin protein, immunoreactivity score of cytoplasmic and membranous staining was used to assess the immunoexpression of fascin in tumor cells. Results: There was a noteworthy correlation discovered between Fascin expression and histological type (p=0.032), and tumor grade (p= 0.02). However, there was no correlation between Fascin expression and age, sex, tumor site, and tumor size. Conclusion: Fascin is a good marker of predicting poorer outcomes in glioma patients, but further work is needed to implement this marker in clinical practice | ||
| Keywords | ||
| Glioma; Glioblastoma multiform; Fascin | ||
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