Detection of Gelsolin in Serum in Patients with Psoriatic Arthritis and Its Correlation with Disease Activity | ||||
| Benha Medical Journal | ||||
| Volume 42, Issue 7, July 2025, Page 838-847 PDF (593.35 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.321737.2204 | ||||
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| Authors | ||||
Sami El Saeed Egaila1; Gamal Abd Elghafar Hamad1; Waleed Ahmad Salah Eldin2; Rasha Abd-Elhamid Al Sayed Ali3; Samar Mahmoud Henedak Mahmoud  4
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| 1Professor of Rheumatology, Rehabilitation and Physical Medicine Department, Benha University, Egypt | ||||
| 2Professor of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Egypt | ||||
| 3Lecturer of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Egypt | ||||
| 4MScs in Rheumatology, Rehabilitation and Physical Medicine, Benha University, Benha, Egypt | ||||
| Abstract | ||||
| Background: Psoriatic arthritis (PsA) is an inflammatory disorder that has effects on the joints of psoriatic patients. Plasma gelsolin levels were studied in many inflammatory and autoimmune disorders. The aim of this study was to investigate the potential role of gelsolin in PsA and to determine the relation of gelsolin to PsA disease activity. Methods: This case control study was carried out on 60 subjects, both sexes, aged above 16 years old who were classified into Group (1) which included 30 patients diagnosed with PsA according to CASPER criteria, and Group (2) which included 30 healthy matched controls in age and sex. Examination of the skin and All body joints was performed on all psoriatic patients. Gelsolin serum level was also assessed. Results: Gelsolin levels show significant negative correlations with CRP, ESR, disease duration, NTJ, NSJ, pain, disease activity, DAPSA score (p < 0.05). In univariable analysis, high CRP, ESR, duration, NTJ, NSJ, pain, activity and lower gelsolin are associated with higher DAPSA. In multivariate analysis, several variables show significant associations with DAPSA. CRP, NTJ, NSJ, pain score, and disease activity in the last week have positive coefficients, indicating that higher values in these variables are associated with higher DAPSA scores. Conclusions: PsA patients have a reduction in the levels of plasma gelsolin. This suggests that gelsolin may be implicated in the chronic joints inflammation process of PsA. Plasma gelsolin seems to be a useful predictive biomarker for diagnosing PsA and monitoring the disease activity. | ||||
| Keywords | ||||
| Gelsolin; Psoriatic Arthritis; Disease Activity | ||||
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